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US 8,557,243 B2Granted
EFGR antibodies comprising modular recognition domains
AssigneeThe Scripps Research Institute
InventorCarlos F. Barbas, III
Life of this patent
Estimating the term…
Abstract
Antibodies containing one or more modular recognition domains (MRDs) that can be used to target the antibodies to specific sites are described. The use of antibodies containing one or more modular recognition domains to treat disease, and methods of making antibodies containing one or more modular recognition domains are also described.
Claims37
A complex comprising an antibody and at least one modular recognition domain (MRD), wherein the antibody binds to EGFR and the MRD competitively inhibits binding of angiopoietin-2 (Ang2) to a polypeptide consisting of the amino acid sequence of SEQ ID NO:8 or SEQ ID NO:21.
Dependencies are inferred from the claim text.