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US 8,557,239 B2Granted
Methods for treating psoriasis using antibodies that bind to the P40 subunit of IL-12 and/or IL-23
AssigneesAbbVie Inc., AbbVie Deutschland GmbH & Co. KG
InventorsJoaquin Mario Valdes, Elliot K. Chartash, William T. Barchuk, Susan K. Paulson, Kenneth B. Gordon, Walid M. Awni, Yanjun Bao, William G. Glass, Yihua Gu, Tom C. Harris, Martin Kaul, Parvez M. Mulani, Peter Noertersheuser, Martin M. Okun
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Abstract
The invention provides methods of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23.
Claims18
A method of treating psoriasis in a subject comprising
- administering to the subject a first dose amount of 180 mg to 220 mg of an antibody, or antigen-binding portion thereof, which is capable of binding to the p40 subunit of IL-12 and/or IL-23, at week 0,
- administering the same first dose amount of the antibody, or antigen-binding portion thereof, to the subject at week 4, and
- administering a second dose amount of 80 mg to 120 mg of the antibody, or antigen-binding portion thereof, to the subject every 4 weeks thereafter, thereby treating psoriasis in the subject.
Dependencies are inferred from the claim text.