Bone substitute compositions, methods of preparation and clinical applications
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Hihger Education
InventorsPrashant Nagesh Kumta, Charles S. Sfeir, Abhijit Roy
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Abstract
The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium phosphate, acidic calcium salt, basic calcium salt, sodium hydrogen phosphate and porogen. The compositions further include a mixing liquid. The compositions can optionally include biological signaling molecules and/or a growth compound. Further, the compositions can optionally include a plasticizer.
Claims14
A method of preparing a bone substitute material, comprising:
- combining calcium phosphate, acidic calcium salt, basic calcium salt, material selected from the group consisting of monosodium hydrogen phosphate, disodium hydrogen phosphate and mixtures thereof, and porogen to form a powder component;
- and
- mixing the powder component with a liquid colloidal mixture comprising nanoparticulate calcium phosphate and calcium salt, the colloidal mixture being complexed with at least one of a compound selected from the group consisting of protein, peptide, DNA, drug, stem cell, normal cell, and combinations thereof,
- wherein the bone substitute material is effective to regenerate bone in the absence of a biological growth component.
Dependencies are inferred from the claim text.