Back to results
US 8,557,222 B2Granted
Radiopharmaceutical imaging of neurodegenerative diseases
AssigneeAvid Radiopharmaceuticals, Inc.
InventorsFranz F. Hefti, Daniel M. Skovronsky, Alan P. Carpenter, Jr.
Life of this patent
Estimating the term…
Abstract
Methods for simultaneously detecting dementia or cognitive impairment, such as Alzheimer's Disease (AD), Parkinson's Disease (PD), Lewy Body Dementia (LBD) and Vascular Dementia (VaD) in a patient using dual or multiple radiopharmaceutical probes are provided herein.
Claims12
A method for detecting or ruling out multiple neurodegenerative diseased states or pathologic processes in a patient comprising:
- administering an effective amount of 18F-AV-45 to a patient, wherein β-amyloid is associated with a first diseased state or pathologic process;
- acquiring an image to detect the presence or absence of β-amyloid plaque in the cortical regions of the brain of the patient;
- administering an effective amount of 18F-AV-133, wherein dopaminergic degeneration of nigrostriatal neurons is associated with a second diseased state or pathologic process;
- acquiring an image to detect dopaminergic degeneration of nigrostriatal neurons in the striatal regions of the brain of the patient;
- detecting the presence or absence of the first diseased state or pathologic process;
- and
- detecting the presence or absence of the second diseased state or pathologic process.
4 more elements
Dependencies are inferred from the claim text.