Delivery of therapeutic substance and marking substance through intra lumen expansion of a delivery device
OwnerSwaminathan Jayaramaninventor
Life of this patent
Estimating the term…
Abstract
The invention provides a balloon catheter formed with a plurality of depressions. The balloon is coated with a matrix incorporating a therapeutic substance, which fills the depressions. When the balloon is expanded within a body lumen, the therapeutic substance may diffuse into the lumen wall, or all or a portion of the coating transfers to the lumen wall. A lattice frame may surround the balloon, applied prior to coating if the coating is to transfer, operative to maintain a more linear balloon profile during inflation, promoting more even transfer pressure. A contrast dye is incorporated into the transferred coating, enabling ready location and inspection of the treated lumen area.
Claims20
A method for delivering a therapeutic substance to an interior wall of a body lumen, comprising:
- providing a catheter including—
- a catheter lumen,
- a balloon operatively-associated with the catheter,
- a resilient flexible lattice frame encircling a portion of the length of the balloon, and
- a coating applied over at least a portion of the lattice frame and an exterior of the balloon, the coating including a therapeutic substance;
- inflating the balloon with inflation pressure exerted by a gas or liquid passed through the catheter lumen;
- and
- expanding the lattice frame with the inflated balloon transferring the coating to the interior wall of a body lumen, where the coating will remain after the deflated balloon and lattice are removed together from the body, after which
- the therapeutic substance within the coating diffuses into the body lumen wall.
A method for delivering a therapeutic substance to an interior wall of a body lumen, comprising:
- providing a catheter including—
- at least one catheter lumen,
- a balloon positioned along the length of the catheter, the balloon inflated through passage of a gas or liquid through at least one of the at least one lumen,
- a resilient flexible lattice frame encircling a portion of the length of the balloon,
- a transfer coating adhered to the lattice with a first adhesion strength, and
- a therapeutic coating adhered to the transfer coating with a second adhesion strength that is relatively weaker than the first adhesion strength, the therapeutic coating including a therapeutic substance,
- inflating the balloon with inflation pressure exerted by a gas or liquid passed through the catheter lumen, the lattice frame expanding together with the inflated balloon, thereby transferring the therapeutic coating to the interior wall of a body lumen;
- and
- deflating the balloon and lattice and removing the catheter together with the balloon and attached lattice, after which the coating will remain and diffuse the therapeutic substance into the body.
A catheter for delivering a therapeutic substance to an interior wall of a body lumen, the catheter comprising:
- a lumen;
- a balloon positioned along the length of the catheter, the balloon inflated through passage of a gas or liquid through at least one of the at least one lumen;
- a resilient flexible lattice frame encircling a portion of the length of the balloon;
- a transfer coating adhered to the lattice with a first adhesion strength;
- a therapeutic coating adhered to the transfer coating with a second adhesion strength that is relatively weaker than the first adhesion strength, the therapeutic coating including a therapeutic substance, the therapeutic coating transferrable to the body lumen upon inflating the balloon with inflation pressure exerted by a gas or liquid passed through the catheter lumen, the lattice frame expanding together with the inflated balloon, the balloon deflatable together with the attached lattice, whereby the balloon and lattice are removable together with the catheter, after which the coating will remain to diffuse the therapeutic substance into the body.
Dependencies are inferred from the claim text.