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US 8,556,842 B2Granted
Perfusion circuit and use therein in targeted delivery of macromolecules
AssigneeThe Trustees of the University of Pennsylvania
InventorsCharles R. Bridges, Hansell H. Stedman, Charles Yarnall
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Abstract
A perfusion circuit and a use thereof for delivering a substance to a subject's heart in situ during cardiopulmonary bypass surgery are provided. The perfusion circuit defines a path for re-circulating a solution containing a macromolecular complex through a coronary circulation circuit through a subject's heart during a surgical procedure in which the substance is prevented from being delivered to the subject's other organs.
Claims20
A method of delivering a macromolecular complex to a subject's heart, said method comprising the steps of:
- (a) forming a cardiac circuit that isolates a subject's cardiac circulation from the subject's systemic circulation;
- and
- (b) perfusing a first macromolecular complex solution into the cardiac circuit in a retrograde manner, wherein said first macromolecular complex solution comprises a viral vector carrying a target molecule, wherein said viral vector is a recombinant adenoviral (rAd) vector or a recombinant adeno-associated viral (rAAV) vector.
Dependencies are inferred from the claim text.