Method and system for determining a cerebrovascular autoregulation state of a patient
AssigneeThe Johns Hopkins University
InventorKen M. Brady
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Abstract
A method of diagnosing cerebrovascular autoregulation in a patient includes measuring blood pressure of the patient, measuring, non-invasively, venous oxygen content of the patient's brain substantially simultaneously with the measuring blood pressure, correlating the blood pressure and the venous oxygen content measurements in a time domain, and determining a cerebrovascular autoregulation state of the patient based on the correlating the blood pressure and the venous oxygen content measurements.
Claims25
A method of diagnosing cerebrovascular autoregulation in a patient, comprising:
- measuring blood pressure of said patient;
- measuring, non-invasively, venous oxygen content of said patient's brain substantially simultaneously with said measuring blood pressure;
- correlating said blood pressure and said venous oxygen content measurements in a time domain;
- and
- determining, using a data processing unit, a cerebrovascular autoregulation state of said patient based on said correlating said blood pressure and said venous oxygen content measurements.
A system for diagnosing cerebrovascular autoregulation in a patient, comprising:
- a cerebral oximeter arranged proximate an external position of said patient's head;
- a blood pressure monitoring device adapted to be attached to said patient;
- and
- a signal processing unit in communication with said cerebral oximeter and said blood pressure monitoring device,
- wherein said cerebral oximeter obtains oxygen content measurements of blood within said patient's brain taken at a plurality of times and outputs an oxygen content signal to said signal processing unit,
- wherein said blood pressure monitoring device obtains arterial blood pressure measurements of said patient at a plurality of times substantially synchronously with said oxygen content measurements and outputs an arterial blood pressure signal to said signal processing unit, and
- wherein said signal processing unit calculates a linear correlation coefficient based on said oxygen content signal and said arterial blood pressure signal in a time domain for a plurality of times.
A method of treating a patient, comprising:
- measuring blood pressure of said patient;
- measuring, non-invasively, venous oxygen content of said patient's brain substantially simultaneously with said measuring blood pressure;
- correlating said blood pressure and said venous oxygen content measurements;
- determining, using a data processing unit, a cerebrovascular autoregulation state of said patient based on said correlating said blood pressure and said venous oxygen content measurements;
- and
- causing a change of blood pressure of said patient based on said cerebrovascular state of said patient determined based on said correlating.
A data processing unit for use with a system for diagnosing cerebrovascular autoregulation in a patient, comprising:
- at least one signal input port adapted to receive an arterial blood pressure signal from measured arterial blood pressure data from said patient and to receive a venous oxygen content signal from externally measured venous oxygen content data of said patient's brain;
- a signal correlation component adapted to receive and correlate said arterial blood pressure signal with said venous oxygen content signal to provide a correlation coefficient indicative of a cerebrovascular autoregulation state of said patient;
- and
- a signal output port to output said correlation coefficient to indicate said cerebrovascular autoregulation state of said patient based on said correlation coefficient.
A data processing unit for use with a system for diagnosing cerebrovascular autoregulation in a patient according to 21, further comprising a low pass filter adapted to filter at least one of said measured arterial blood pressure data and said externally measured venous oxygen content data prior to being correlated by said signal correlation component.
A data processing unit for use with a system for diagnosing cerebrovascular autoregulation in a patient according to 21, wherein said at least one signal input port is adapted to also receive an intracranial pressure signal from measured intracranial pressure data from said patient.
A data processing unit for use with a system for diagnosing cerebrovascular autoregulation in a patient according to 23, further comprising a cerebral perfusion pressure calculating unit adapted to calculate cerebral perfusion pressure based on said measured arterial blood pressure data and said measured intracranial pressure data.
A non-transient computer readable medium programmed to process data for a system for diagnosing cerebrovascular autoregulation in a patient, comprising:
- at least one signal receiving component adapted to receive a blood pressure signal from measured blood pressure data from said patient and to receive a venous oxygen content signal from externally measured venous oxygen content data of said patient's brain;
- a signal correlation component adapted to receive and correlate said arterial blood pressure signal with said venous oxygen content signal to provide a correlation coefficient indicative of a cerebrovascular autoregulation state of said patient;
- and
- a signal output component adapted to output said correlation coefficient to indicate said cerebrovascular autoregulation state of said patient based on said correlation coefficient.
Dependencies are inferred from the claim text.