Control of interface between separated blood components under lipemic and hemolytic conditions

A method of separating blood into one blood component and other blood components, comprising:

• separating blood in a blood separation chamber into at least one blood component and a different other blood component;
• monitoring the interior of the blood separation chamber with a first optical sensor assembly;
• removing at least a portion of the at least one blood component from the blood separation chamber;
• monitoring, while blood is being separated, the at least one blood component removed from the blood separation chamber with a second optical sensor assembly;
• and
• selecting, while blood is being separated, only one of the first optical sensor assembly or the secondary optical sensor assembly for detecting the presence of said different other blood component in the at least one blood component, wherein the first optical sensor assembly is selected under a first condition in which the at least one blood component has a first light transmissivity and wherein the second optical sensor assembly is selected under a second condition in which the at least one blood component has a second light transmissivity.