Hybrid organic/inorganic chemical hybrid systems, including functionalized calcium phosphate hybrid systems, and a solid-state method for producing the same

A solid state mechanochemical method for producing functionalized chemical compounds, comprising:

• combining a first predetermined amount of crystalline tricalcium phosphate with a second predetermined amount of an organic material to yield an admixture;
• placing the admixture in a reaction vessel;
• imparting sufficient energy to the reaction vessel to at least partially convert at least some of the crystalline tricalcium phosphate and organic materials to respective intermediate crystalline tricalcium phosphate and intermediate organic particles of reduced size;
• imparting sufficient kinetic energy to the respective crystalline tricalcium phosphate and organic intermediate particles to fuse at least some of the respective crystalline tricalcium phosphate and organic intermediate particles together to yield functionalized chemical compounds.

A solid-state method of producing fluoridated functionalized compounds, comprising:

• a) combining a first predetermined amount of crystalline tricalcium phosphate with a second predetermined amount of an organic material to define an admixture;
• b) placing the admixture in a milling vessel operationally connected to a planetary mill;
• c) introducing milling media into the milling vessel;
• d) milling the admixture to impart sufficient kinetic energy to break down the organic material and crystalline tricalcium phosphate into substantially smaller intermediate particles;
• e) milling the admixture with sufficient energy to fuse the intermediate particles together to yield functionalized molecules having both organic and crystalline tricalcium phosphate chemical characteristics
• f) combining the functionalized molecules having both organic and crystalline tricalcium phosphate characteristics with a fluoridated formulation to yield a fluoridated hybrid compound.

A solid-state method of producing functionalized compounds, comprising:

• a) combining a predetermined amount of crystalline tricalcium phosphate with a predetermined amount of an organic material to yield an admixture;
• b) placing the admixture in a milling vessel;
• c) introducing milling media into the milling vessel;
• d) milling the admixture to break down the organic and inorganic crystalline tricalcium phosphate materials into substantially smaller intermediate particles;
• and
• e) milling the admixture to fuse the intermediate particles together to yield functionalized compounds having both organic and inorganic crystalline chemical characteristics and a particle size of at least 100 nanometers.