Method and apparatus for analyzing genotype data

#This application claims the benefit of Korean Patent Application No. 10-2005-0000382, filed on Jan. 4, 2005, in the Korean Intellectual Property Office, the disclosure of which is incorporated herein in its entirety by reference.

#1. Field of the Invention

#The present invention relates to a method and apparatus for analyzing genotype data plotted in a two-dimensional space, and more particularly, to a method and apparatus for analyzing genotype data in which the two largest angles obtained by connecting straight lines between points representing the genotype data and a predetermined point plotted in a two-dimensional space are detected and three data regions separated by the detected two angles are used to analyze the experimental results of classifying the genotype data.

#The above and other features and advantages of the present invention will become more apparent by describing in detail exemplary embodiments thereof with reference to the attached drawings in which:

#FIG. 1 is a graph illustrating genotype data plotted in a two-dimensional space;

#FIG. 2 is another graph illustrating genotype data plotted in a two-dimensional space;

#Hereinafter, a method and apparatus for analyzing genotype data according to embodiments of the present invention will be described in more detail with reference to the attached drawings.

#FIG. 1 is a graph illustrating genotype data plotted in a two-dimensional space in which a first signal-to-noise ratio (SNR)1 indicating a distribution of A1 in the experimental data and an SNR2 indicating a distribution of A2 in the experimental data are calculated and plotted. In the case of homozygote 1 expressed by A1A1, the amount of A1 is very large and SNR1 is much greater than SNR2, and thus, the genotype data expressed by A1A1 are plotted on straight line 100. In the case of heterozygote expressed by A1A2, the amount of A1 is nearly the same as the amount of A2 and SNR1 is nearly the same as SNR2, and thus, the genotype data expressed by A1A2 are plotted on straight line 110. In the case of homozygote 2 expressed by A2A2, the amount of A2 is very large and SNR2 is much greater than SNR1, and thus, the genotype data expressed by A2A2 are plotted on straight line 120

#FIG. 2 is another graph illustrating genotype data plotted in a two-dimensional space. In theory, the ratio of SNR1 to SNR2 should be constant for each genotype and, when the genotype data are plotted in the two-dimensional space, the genotype data should be plotted on straight lines having different gradients, as illustrated in FIG. 1. However, when SNR1 and SNR2 of the genotype data determined by experiment are calculated and plotted in the two-dimensional space, points representing the determined genotype data are located around straight lines 100, 110, and 120 as illustrated in FIG. 2.