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US 8,554,296 B2Granted
Photoacoustic measurement of analyte concentration in the eye
OwnerGholam A. Peymaninventor
Life of this patent
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Abstract
An in vivo determination of the presence or concentration of an endogenous or exogenous substance by photoacoustically assaying the substance in the eye and correlating the presence or concentration of the substance in the eye to the presence or concentration of the substance in the blood, without removing a tissue or fluid sample from the body for assay. The eye, unlike other body sites such as the skin, has a relatively constant pressure and temperature, providing an additional utility for the inventive method.
Claims18
A method of measuring the blood concentration of a liquid or gaseous substance within a fluid present in an eye, the method comprising
- illuminating the fluid present in the eye with a light source at a frequency that is absorbed by the liquid or gaseous substance to be measured,
- sensing only photoacoustically generated pulses or modulating acoustic signals originated within the liquid or gaseous fluid as a consequence of illumination by the light source, without light being reflected or otherwise directed to a detector,
- estimating blood concentration of the liquid or gaseous substance from an amplitude of received pulses or modulating acoustic signals, and
- displaying the estimated blood concentration.
1 more element
Dependencies are inferred from the claim text.