Anti-TIM-3 antibody

A monoclonal antibody or an antigen-binding fragment thereof, which is one selected from the following (a) to (e):

• (a) a monoclonal antibody or an antigen-binding fragment thereof, each comprising a heavy chain (H chain) and a light chain (L chain), wherein complementarity determining regions (CDRs) 1 to 3 of said H chain comprises the amino acid sequences of SEQ ID NOs:
• 1 to 3, respectively, and CDRs 1 to 3 of said L chain comprises the amino acid sequences of SEQ ID NOs:
• 4 to 6, respectively,
• (b) a monoclonal antibody or an antigen-binding fragment thereof, each comprising an H chain and a L chain, wherein CDRs 1 to 3 of said H chain comprises the amino acid sequences of SEQ ID NOs:
• 11 to 13, respectively, and CDRs 1 to 3 of said L chain comprises the amino acid sequences of SEQ ID NOs:
• 14 to 16, respectively,
• (c) a monoclonal antibody or an antigen-binding fragment thereof, each comprising an H chain and a L chain, wherein CDRs 1 to 3 of said H chain comprises the amino acid sequences of SEQ ID NOs:
• 21 to 23, respectively, and CDRs 1 to 3 of said L chain comprises the amino acid sequences of SEQ ID NOs:
• 24 to 26, respectively,
• (d) a monoclonal antibody or an antigen-binding fragment thereof, each comprising an H chain variable region (VH) and a L chain variable region (VL), wherein said VH and VL comprises the amino acid sequences of SEQ ID NO:
• 8 and SEQ ID NO:
• 10, respectively, and
• (e) a monoclonal antibody or an antigen-binding fragment thereof, each comprising VH and VL, wherein said VH and VL comprises the amino acid sequences of SEQ ID NO:
• 18 and SEQ ID NO:
• 20, respectively.