Pharmaceutical compositions of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid and administration thereof

A pharmaceutical composition comprising a plurality of granules, the composition comprising:

• a. 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid Form I, 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid Form II, and/or 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid HCl Salt Form A in an amount ranging from about 20 wt% to about 80 wt% by weight of the composition;
• b. a filler in an amount ranging from about 20 wt% to about 50 wt% by weight of the composition of a filler;
• c. a disintegrant in an amount ranging from a from about 1 wt% to about 5 wt% by weight of the composition;
• d. a surfactant in an amount ranging from about 2 wt% to about 0.3 wt% by weight of the composition;
• e. a diluent in an amount ranging from about 1 wt% to about 30 wt% by weight of the composition;
• f. a lubricant in an amount ranging from about 0.3 wt% to about 5 wt% by weight of the composition;
• and
• g. at least one of a binder in an amount from about 20 wt% to about 45 wt% by weight of the composition or a glidant in an amount ranging from about 0.05 wt% to about 2 wt% by weight of the composition.

A method of producing a pharmaceutical composition comprising the steps of:

• combining a therapeutically effective amount of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid Form I, 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid Form II, and/or 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid HCl Salt Form A and at least one granulation excipient selected from the group consisting of:
• a binder;
• a glidant;
• a surfactant;
• a lubricant;
• a disintegrant;
• a filler, a diluent and combinations thereof to form an admixture;
• mixing the admixture;
• and compacting the admixture to form the pharmaceutical composition.