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US 8,551,781 B2Granted
Vault complexes for facilitating biomolecule delivery
AssigneesThe Regents of the University of California, The Scripps Research Institute
InventorsLeonard H. Rome, Valerie A. Kickhoefer, Glen R. Nemerow, Cheng-Yu Lai, Christopher M. Wiethoff, Mu Ri Han
Life of this patent
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Abstract
The invention relates to compositions of vault complexes containing recombinant membrane lytic proteins, such as an adenovirus protein VI lytic domain, and methods of using the vault complexes to facilitate delivery and entry of a biomolecule into a cell or subject.
Claims3
A vault-like particle comprising a membrane lytic domain comprising the amino acid sequence of SEQ ID NO:3, a major vault protein comprising the amino acid sequence of SEQ ID NO:16, and an antibody binding Z domain.
Dependencies are inferred from the claim text.