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US 8,551,756 B2Granted
Avian influenza chimeric VLPS
AssigneeNovavax, Inc.
InventorsGale Smith, Peter Pushko
Life of this patent
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Abstract
This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also comprises methods of making and using said VLPs.
Claims15
A method of increasing the efficiency of influenza virus-like particle (VLP) production comprising expressing an avian influenza matrix (M1) protein and at least one non-avian influenza protein in a host cell,
- wherein the avian influenza M1 protein is derived from A/Indonesia/5/05 influenza, and
- whereby increased VLP production is obtained in the host cell comprising the avian influenza M1 protein compared to a host cell expressing a non-avian influenza M1 protein.
Dependencies are inferred from the claim text.