Bridged heterocyclic compounds and methods of use
AssigneeMedivation Technologies, Inc.
InventorsDavid T. Hung, Andrew Asher Protter, Sarvajit Chakravarty, Rajendra Parasmal Jain
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Abstract
This disclosure relates to new compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new bridged heterocyclic [4,3-b]indole compounds. Pharmaceutical compositions are also provided. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
Claims11
A compound, or a salt thereof, wherein the compound is selected from the group consisting of compounds:
- Com-
- pound #
- Structure
- 1
- 2
- 3
- 4
- 5
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- 7
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- 9
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A compound of the formula (A-2):
- wherein:
- R1 is unsubstituted C1-C8 alkyl;
- each X7, X8, X9 and X10 is independently N or CR4;
- each R4 is independently H, hydroxyl, nitro, cyano, halo, C1-C8 perhaloalkyl, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C2-C8 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, C1-C8 perhaloalkoxy, C1-C8 alkoxy, aryloxy, carboxyl, thiol, carbonylalkoxy, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aralkyl, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl, carbonylalkylenealkoxy, alkylsulfonylamino or acyl;
- q is 0;
- each R8c, R8d and R8f is independently H, hydroxyl, C1-C8 alkyl, C1-C8 perhaloalkyl, carboxy or carbonylalkoxy;
- R8e is independently hydroxyl, C1-C8 alkyl, C1-C8 perhaloalkyl, carboxy or carbonylalkoxy;
- and
- Q is a substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C3-C8 cycloalkenyl, substituted or a unsubstituted heterocyclyl, unsubstituted amino, substituted amino, alkoxy, aminoacyl, acyloxy, carbonylalkoxy, aminocarbonylalkoxy or acylamino;
- or a salt thereof.
A compound of the formula (A-2):
- or a salt thereof, wherein:
- each X8 and X9 is independently CR4 where R4 is H, halo or methyl,
- each X7 and X10 is CH,
- R1 is methyl,
- q is 0 or 1,
- each R8a and R8b is H when present,
- each R8c and R8d is H,
- each R8e and R8f is independently H, hydroxy or methyl, and
- Q is selected from the group consisting of:
A compound of the formula (B):
- or a salt thereof, wherein:
- R1 is methyl;
- each R2, R3a, R3b and R10 is H;
- p is 1;
- each X7, X8, X9 and X10 is independently N or CR4;
- each R4 is independently H, hydroxyl, nitro, cyano, halo, C1-C8 perhaloalkyl, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C2-C8 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, C1-C8 perhaloalkoxy, C1-C8 alkoxy, aryloxy, carboxyl, carbonylalkoxy, thiol, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aralkyl, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl, carbonylalkylenealkoxy, alkylsulfonylamino or acyl;
- each R8c, R8d, R8e and R8f is independently H, hydroxyl, unsubstituted C1-C4 alkyl or is taken together with the carbon to which it is attached and a geminal R8 to form a cycloalkyl moiety;
- and
- Q is substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl, provided that Q is other than phenyl.
Dependencies are inferred from the claim text.