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US 8,546,357 B2Granted
Boron-containing small molecules for controlling ectoparasites
AssigneesEli Lilly and Company, Anacor Pharmaceuticals, Inc.
InventorsTsutomu Akama, Terry William Balko, Jean Marie Defauw, Jacob J. Plattner, William Hunter White, Joseph Raymond Winkle, Yong-Kang Zhang, Yasheen Zhou
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Abstract
This invention provides novel compounds, methods of using the compounds, and pharmaceutical compositions containing the compounds.
Claims36
A compound having a structure of formula I or II:
- wherein
- A is
- where * is bonded to the carbonyl;
- Y is hydrogen, fluoro, chloro, or bromo;
- R1 is phenyl substituted 2-4 times, said substitutions comprising i) 1-4 substitutions with the same or different of halo, and 0-1 substitutions with methyl, difluoromethyl, trifluoromethyl, methoxy, trifluoromethoxy, or trifluoroethoxy, or ii) 2 trifluoromethyl groups;
- R2 is methyl, fluoromethyl, trifluoromethyl, or perfluoroethyl;
- R3a and R3b are independently selected from hydrogen, methyl, ethyl, fluoromethyl, or R3a and R3b combine with the carbon to which they are attached to form a cyclopentyl ring or a cyclohexyl ring;
- Z is —CH2—, —CH2—CH2—, —CH(CH3)—, or —C(CH3)2—;
- and
- R6 is hydrogen or methyl;
- or a salt thereof.
8 more elements
Dependencies are inferred from the claim text.