US 8,545,850 B2 · Anti-CD79B antibodies and immunoconjugates and methods of use

Abstract

The present invention is directed to compositions of matter comprising immunoconjugates comprising an anti-CD79b antibody comprising: (i) an HVR-L1 sequence of KASQSVDYEGDSFLN (SEQ ID NO: 194), (ii) an HVR-L2 sequence of AASNLES (SEQ ID NO: 195), (iii) an HVR-L3 sequence of QQSNEDPLT (SEQ ID NO: 196), (iv) an HVR-H1 sequence of GYTFSSYWIE (SEQ ID NO: 202), (v) an HVR-H2 sequence of GEILPGGGDTNYNEIFKG (SEQ ID NO: 203), and (vi) an HVR-H3 sequence of TRRVPIRLDY (SEQ ID NO: 204) and to methods of using those compositions of matter for the treatment of hematopoietic tumor in mammals.

Claims8

Dependent claims

An immunoconjugate comprising an anti-CD79b antibody comprising:

(i) an HVR-L1 sequence of KASQSVDYEGDSFLN (SEQ ID NO:
194)
(ii) an HVR-L2 sequence of AASNLES (SEQ ID NO:
195)
(iii) an HVR-L3 sequence of QQSNEDPLT (SEQ ID NO:
196)
(iv) an HVR-H1 sequence of GYTFSSYWIE (SEQ ID NO:
202)
(v) an HVR-H2 sequence of GEILPGGGDTNYNEIFKG (SEQ ID NO:
203), and
(vi) an HVR-H3 sequence of TRRVPIRLDY (SEQ ID NO:
204),
wherein said antibody is covalently attached to a cytotoxic agent.

10 more elements

Dependencies are inferred from the claim text.

Facts

Application

12/940,435Filed 5 Nov 2010 · continuation

Priority

16 Jul 2007

Published

US 2011/0135667 A19 Jun 2011

Granted

1 Oct 2013

Term ends

Not estimatedThe source records don’t support an estimate.

Classification36 codes

C07K 16/2803
Against receptors, cell surface antigens or cell surface determinants: against the immunoglobulin superfamily
A61K 31/537
Having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines: spiro-condensed or forming part…
A61K 38/05
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof: dipeptides
A61K 39/3955
Against materials from animals: against proteinaceous materials, e.g. enzymes, hormones, lymphokines

Family

Application60/950,052Us provisional application · filed 16 Jul 2007

Application61/025,137Us provisional application · filed 31 Jan 2008

Application61/032,790Us provisional application · filed 29 Feb 2008

Application61/054,709Us provisional application · filed 20 May 2008

Application12/173,465Parent of this continuation · filed 15 Jul 2008

US 2011/0135667 A1Pre-grant publication · published 9 Jun 2011

US 8,088,378 B2Parent of this continuation · filed 3 Jan 2012

US 2009/0028856 A1Published application

US 8,545,850 B2This patent

From the US filing history. Foreign family members aren’t listed.

Anti-CD79B antibodies and immunoconjugates and methods of use

Life of this patent

Anti-CD79B antibodies and immunoconjugates and methods of use

Life of this patent

Abstract

Claims8