Solid composition for the oral administration of dyes and diagnostic use thereof
AssigneeCosmo Technologies Limited
InventorsLuigi Moro, Mauro Severino Ajani, Roberto Villa, Giuseppe Celasco, Alessandro Repici
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Abstract
The present application discloses solid compositions for the oral administration of dyes, and diagnostic use thereof. Preferably, such diagnostic use is aimed at the diagnostic evaluation of the gastrointestinal tract.
Claims22
A method of endoscopic diagnostic evaluation of pathologies of the gastrointestinal tract in a subject, said method comprises administering to the subject a diagnostically effective amount of at least one solid composition within a 24 hour period preceding the endoscopic diagnostic evaluation and endoscopic diagnostically evaluating the gastrointestinal tract for said pathologies, wherein said solid composition is for oral administration and comprises:
- (a) methylene blue;
- (b) a first matrix in which said methylene blue is incorporated, wherein said first matrix comprises stearic acid or magnesium stearate and lecithin;
- (c) a second matrix comprising methylhydroxypropyl cellulose, wherein the first matrix is dispersed in the second matrix;
- (d) optionally other physiologically acceptable excipients;
- and
- (e) optionally a gastro-resistant coating.
A method of endoscopic diagnostic evaluation of pathologies of the gastrointestinal tract in a subject, said method comprises administering to the subject a diagnostically effective amount of at least one solid composition and endoscopic diagnostically evaluating the gastrointestinal tract for said pathologies, wherein said solid composition is for oral administration and comprises:
- (a) methylene blue;
- (b) a first matrix in which said methylene blue is incorporated, wherein said first matrix comprises stearic acid or magnesium stearate;
- and lecithin;
- (c) a second matrix comprising methylhydroxypropyl cellulose, wherein the first matrix is dispersed in the second matrix;
- (d) optionally other physiologically acceptable excipients;
- and
- (e) optionally a gastro-resistant coating.
Dependencies are inferred from the claim text.