# US 8,543,219 B2 · Device for modulation of neuronal activity in the brain by means of sensory stimulation and detection of brain activity

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- Number: US 8,543,219 B2
- Document ID: US8543219B2
- Status: Granted
- Kind: B2
- Application number: 10/522,933
- Filed: 2003-07-05
- Published: 2006-03-02
- Granted: 2013-09-24
- Earliest claimed: 2002-07-29
- Assignees: Forschungszentrum Julich GmbH
- Applicants: Peter Tass
- Inventors: Peter Tass
- Web page: https://patentgrep.com/patent/US8543219B2

## CPC

- A61B 5/4064: {Evaluating the brain (for intracranial pressure A61B5/031; for cerebral blood gases A61B5/14553; using EEG A61B5/369)}
- A61B 5/375: using biofeedback
- A61B 5/377: using evoked responses
- A61M 21/00: Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
- A61B 5/378: Visual stimuli
- A61B 5/38: Acoustic or auditory stimuli
- A61M 2230/10: Electroencephalographic signals
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

The invention relates to a device for controlled modulation of physiological and pathological neuronal rhythmic activity in the brain by means of sensory stimulation, which is capable of diagnostically ascertaining functional disorders in the brain and of alleviating or eliminating the symptoms of a functional disruption. According to the invention, the device comprises a control unit (4), a stimulator (1) and at least one means for detecting brain activity, said means being connected to the control unit (1).

## Claims

### Claim 1

A device for desynchronizing pathologically rhythmic brain activity, the device comprising:
a stimulator configured to generate a plurality of pulses at a plurality of excitation frequencies, respectively, to stimulate neuronal rhythmic activity in a patient's brain;
a sensor configured to measure the neuronal rhythmic activity in response to the plurality of pulses; and
a control unit configured to determine at least one frequency of the plurality of excitation frequencies in which the sensor measures a maximum excitation of the neuronal rhythmic activity in response to the plurality of pulses;
wherein the control unit is further configured to control the stimulator to generate an entraining periodic pulse sequence operating at the at least one frequency to entrain the phase dynamic of the neuronal rhythmic activity,
wherein the stimulator is further configured to generate a desynchronization pulse following the entraining periodic pulse sequence to desynchronize the neuronal rhythmic activity, and
wherein the plurality of pulses, the entraining pulse sequence and the desynchronization pulse are either visual or acoustic or tactile.

### Claim 2 (depends on 1)

The device according to claim 1, wherein the control unit is further configured to determine the vulnerable phase of the neuronal rhythmic activity, and wherein the stimulator is further configured to generate the desynchronization pulse at the vulnerable phase.

### Claim 3 (depends on 2)

The device according to claim 2, wherein the control unit is further configured to determine optimal stimulation parameters based a series of test stimulations.

### Claim 4 (depends on 3)

The device according to claim 3, wherein the control unit is further configured to determine a minimization of the amplitude of the neuronal rhythmic activity to be desynchronized.

### Claim 5 (depends on 4)

The device according to claim 4, wherein the control unit is further configured to perform a Hilbert transformation to determine the minimization of the amplitude of the stimulation parameters.

### Claim 6 (depends on 4)

The device according to claim 4, wherein the control unit is further configured to match a slowly changing sine function to a signal of the sensor in a time window following stimulation to determine the minimization of the amplitude of the stimulation parameters giving rise to a desynchronization of the neuronal rhythmic activity.

### Claim 7 (depends on 4)

The device according to claim 4, wherein the control unit is further configured to integrate the amplitude of the power spectrum over the frequency band of signals measured by the sensor in a time window following the stimulation to determine the minimization of the amplitude of the stimulation parameters giving rise to a desynchronization of the neuronal rhythmic activity.

### Claim 8 (depends on 2)

The device according to claim 2, wherein the control unit determines the vulnerable phase by varying the time spacing between the last excitation of the entraining periodic pulse sequence and the desynchronization pulse.

### Claim 9 (depends on 8)

The device according to claim 8, wherein the control unit is further configured to effect a variation in the time spacing for different values of the intensity.

### Claim 10 (depends on 8)

The device according to claim 8, wherein the control unit is further configured to increase the intensity in equidistant steps.

### Claim 11 (depends on 1)

The device according to claim 1, wherein the control unit is further configured to calculate phase resetting curves.

### Claim 12 (depends on 11)

The device according to claim 11, wherein the control unit is further configured to evaluate the phase resetting curves to measure the desynchronized neuronal rhythmic activity.

### Claim 13 (depends on 12)

The device according to claim 12, wherein the control unit is further configured to apply the phase dynamic of the neuronal rhythmic activity before stimulation over the phase dynamic of the neuronal rhythmic activity after stimulation to evaluate the phase resetting curves.

### Claim 14 (depends on 12)

The device according to claim 12, wherein the control unit is further configured to determine the position of the phase resetting curve at which the transition from a main rise 1 to a main rise 0 to evaluate the phase resetting curves.

### Claim 15 (depends on 11)

The device according to claim 11, further comprising a display screen configured to display the phase resetting curves.

### Claim 16 (depends on 11)

The device according to claim 11, wherein the control unit is further configured to quantitatively characterize calculate the phase resetting curves.

### Claim 17 (depends on 1)

The device according to claim 1, wherein the control unit is further configured to determine the quality of the entrainment of the phase dynamic of the neuronal rhythmic activity.

### Claim 18 (depends on 17)

The device according to claim 17, wherein the control unit is further configured to measure at least one of the phase dynamic and the amplitude of the neuronal rhythmic activity.

### Claim 19 (depends on 18)

The device according to claim 18, wherein the control unit is further configured to perform means for determining the phase and amplitude of the neuronal rhythm to be desynchronized carries out a Hilbert transformation or a matching of the signals of the neuronal rhythmic activity with a slowly changing sine function in a sliding time window.

### Claim 20 (depends on 1)

The device according to claim 1, wherein the sensor is further configured to measure the neuronal rhythmic activity before the stimulator generates a plurality of pulses, and wherein the control unit is configured to determine whether to perform need-controlled synchronization of the neuronal rhythmic activity of the patient's brain based on the neuronal rhythmic activity measured without stimulation.

### Claim 21 (depends on 20)

The device according to claim 20, wherein the stimulator is further configured to generate a periodic succession of pulses to excite the neuronal rhythmic activity of the patient's brain.

### Claim 22 (depends on 1)

The device according to claim 1, wherein the stimulator is at least one component selected from the group comprising a display screen, a pair of shutter-equipped eyeglasses, a loud speaker, headphones, a pressure generator and a time modulated laser.

### Claim 23 (depends on 1)

The device according to claim 1, wherein the sensor is at least one component selected from the group comprised of a scalp EEG electrode and a MEG electrode.

### Claim 24 (depends on 1)

The device according to claim 1, wherein the sensor is coupled to the control unit via an isolating amplifier.

### Claim 25 (depends on 1)

The device according to claim 1, further comprising an input configured to receive feedback from the patient.

### Claim 26 (depends on 1)

The device according to claim 1, wherein the sensor is further configured to evoke physiological and/or pathological brain activity.

### Claim 27 (depends on 1)

The device according to claim 1, wherein the control unit is further configured to quantify the amplitude of the power spectrum over the plurality of excitation frequencies and to quantify the instantaneous amplitude of the plurality of excitation frequencies as determined by the Hilbert transformation.

### Claim 28 (depends on 1)

The device according to claim 1, wherein the control unit is further configured to actuate the stimulator.

### Claim 29 (depends on 1)

The device according to claim 1, wherein the control unit is further configured to execute a Fourier transformation or a wavelet analysis on the measured neuronal rhythmic activity.

### Claim 30 (depends on 1)

The device according to claim 1 wherein the desynchronization pulse follows the entraining periodic pulse sequence with a predetermined time delay.

### Claim 31 (depends on 1)

The device according to claim 1, wherein the stimulator is configured to vary the intensity of the plurality of pulses such that the control unit can determine an intensity at which the strongest desynchronization of pathologically rhythmic brain waves is effected.

### Claim 32 (depends on 1)

The device according to claim 1, wherein the plurality of pulses range between frequencies of 1 and 100 Hz.