# US 8,541,764 B2 · Method of utilizing an implant for targeting external beam radiation > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,541,764 B2 - Document ID: US8541764B2 - Status: Granted - Kind: B2 - Application number: 13/567,303 - Filed: 2012-08-06 - Published: 2012-11-29 - Granted: 2013-09-24 - Earliest claimed: 1997-10-10 - Assignees: SenoRx, Inc. - Applicants: John Corbitt; Lori Anthony - Inventors: John Corbitt; Lori Anthony - Web page: https://patentgrep.com/patent/US8541764B2 ## CPC - A61F 2/12: Mammary prostheses - A61B 90/39: {Markers, e.g. radio-opaque or breast lesions markers} - A61N 5/10: X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy (A61N5/01 takes precedence) - A61N 5/1049: {for verifying the position of the patient with respect to the radiation beam} - A61B 2090/3908: {Soft tissue, e.g. breast tissue} - A61B 2090/3966: {Radiopaque markers visible in an X-ray image} - A61F 2250/0098: radio-opaque, e.g. radio-opaque markers - A61N 2005/1061: {using an x-ray imaging system having a separate imaging source} - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract A method of partial breast radiation therapy includes placing within a breast cavity a substantially radio-opaque implant constructed of biocompatible material, said substantially radio-opaque implant supporting the tissue surrounding the breast cavity; and directing a radiation beam to said substantially radio-opaque implant serving as a target for delivery of radiation therapy to margins around the breast cavity, such that the radiation beam does not materially irradiate the whole of the breast. ## Claims ### Claim 1 A method of partial breast radiation therapy comprising: placing within a breast cavity a substantially radio-opaque implant constructed of biocompatible material, said substantially radio-opaque implant supporting the breast tissue surrounding the breast cavity; and directing a radiation beam to said substantially radio-opaque implant serving as a target for delivery of radiation therapy to margins around the breast cavity, such that the radiation beam does not materially irradiate the whole of the breast. ### Claim 2 (depends on 1) The method of claim 1, wherein the radiation therapy is delivery of a therapeutically effective dosage of radiation to said breast tissue surrounding the substantially radio-opaque implant via a stereotactic radiation machine. ### Claim 3 (depends on 2) The method of claim 2, wherein the radiation therapy is delivery of multiple therapeutically effective dosages of radiation to said breast tissue surrounding the substantially radio-opaque implant in a single treatment. ### Claim 4 (depends on 1) The method of claim 1, wherein the radiation therapy is delivery of therapeutically effective dosages of radiation to said breast tissue surrounding the substantially radio-opaque implant multiple times in a single treatment. ### Claim 5 (depends on 1) The method of claim 1, wherein the radiation therapy is delivery of a therapeutically effective dosage of radiation to said breast tissue surrounding the substantially radio-opaque implant via multidirectional radiation therapy. ### Claim 6 (depends on 1) The method of claim 1, wherein the radiation therapy is delivery of a therapeutically effective dosage of radiation to said breast tissue surrounding the substantially radio-opaque implant via image guided radiation therapy. ### Claim 7 (depends on 1) The method of claim 1, wherein the radiation therapy is delivery of a therapeutically effective dosage of radiation to said breast tissue surrounding the substantially radio-opaque implant via 3-D conformal radiation therapy. ### Claim 8 (depends on 1) The method of claim 1, wherein the radiation therapy is delivery of a therapeutically effective dosage of radiation to said breast tissue surrounding the substantially radio-opaque implant via intensity modulated radiation therapy. ### Claim 9 (depends on 1) The method of claim 1, wherein the breast cavity is a lumpectomy cavity, and further comprising the step of aspirating air from the lumpectomy cavity at any time after placement of the substantially radio-opaque implant. ### Claim 10 (depends on 1) The method of claim 1 comprising initiating targeting of the radiation beam for delivery of the radiation therapy 1 to 120 days subsequent to the placement of the substantially radio-opaque implant in the breast cavity. ### Claim 11 (depends on 1) The method of claim 1, wherein the substantially radio-opaque implant is constructed of a porous biodegradable material. ### Claim 12 (depends on 1) The method of claim 1, wherein said substantially radio-opaque implant has a shape selected to guide the delivery of radiation therapy to the margins around the breast cavity. ### Claim 13 A method of partial breast radiation therapy, comprising: providing a substantially radio-opaque implant constructed of biocompatible material, the substantially radio-opaque implant being configured to support the tissue surrounding a breast cavity; placing the substantially radio-opaque implant within the breast cavity to serve as a target for delivery of radiation therapy to margins around the breast cavity; and directing a therapeutically effective dosage of radiation to the substantially radio-opaque implant target such that the whole of the breast is not materially irradiated. ### Claim 14 (depends on 13) The method of claim 13 further comprising initiating targeting of the delivery of the radiation therapy 1 to 120 days subsequent to the placement of the substantially radio-opaque implant in the breast cavity. ### Claim 15 (depends on 13) The method of claim 13, wherein the substantially radio-opaque implant is constructed of a porous biodegradable material. ### Claim 16 (depends on 13) The method of claim 13, wherein said substantially radio-opaque implant has a shape selected to guide the delivery of radiation therapy to the margins around the breast cavity. ### Claim 17 A method of partial breast radiation, comprising: placing within a breast lumpectomy cavity a substantially radio-opaque implant constructed of biocompatible material configured to provide support to the tissue surrounding the breast lumpectomy cavity; and directing a radiation beam to said substantially radio-opaque implant serving as a target for delivery of radiation therapy to margins around the breast lumpectomy cavity, such that the radiation beam does not materially irradiate the whole of the breast. ### Claim 18 (depends on 17) The method of claim 17, wherein the substantially radio-opaque implant is constructed of a biodegradable material. ### Claim 19 (depends on 17) The method of claim 17, wherein said substantially radio-opaque implant has a shape selected to guide the delivery of radiation therapy to the margins around the breast lumpectomy cavity. ### Claim 20 (depends on 17) The method of claim 17, wherein said substantially radio-opaque implant is constructed of a porous material.