# US 8,541,762 B2 · Charged particle irradiation device and method > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,541,762 B2 - Document ID: US8541762B2 - Status: Granted - Kind: B2 - Application number: 13/637,096 - Filed: 2011-03-30 - Published: 2013-01-31 - Granted: 2013-09-24 - Earliest claimed: 2010-03-31 - Assignees: Ion Beam Applications S.A. - Applicants: Yves Claereboudt; Gregory Saive - Inventors: Yves Claereboudt; Gregory Saive - Web page: https://patentgrep.com/patent/US8541762B2 ## CPC - A61N 5/00: Radiation therapy (ultrasound therapy A61N7/00; devices or apparatus applicable to both therapy and diagnosis A61B6/00) - A61N 5/1043: {Scanning the radiation beam, e.g. spot scanning or raster scanning} - A61N 5/1048: {Monitoring, verifying, controlling systems and methods} - A61N 5/1065: {Beam adjustment} - A61N 2005/1074: {Details of the control system, e.g. user interfaces} - A61N 2005/1087: {Ions; Protons} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract A charged particle irradiation device (10) and method for irradiating a target volume (50), adapted for receiving a treatment plan (70) defining a series of prescribed irradiation points (140) having each a prescribed dose to be delivered is provided. The device includes an irradiation unit (40) having at least one scanning magnet (100; 110), and at least one beam position monitor (130) installed in between the said scanning magnet (100; 110) and said target volume (50) is provided. A controller (80) comprises means for calculating for any said prescribed irradiation point corresponding nominal magnetic settings of the scanning magnet such that a beam (90) is pointing to said prescribed irradiation point when corresponding magnetic settings are applied, and means for calculating corresponding expected position at said beam position monitor (130) according to said first correction. ## Claims ### Claim 1 A charged particle irradiation device (10) for irradiating a target volume (50), adapted for receiving a treatment plan (70) defining a series of prescribed irradiation points (140) having each a prescribed dose to be delivered, comprising an accelerator (20), a beam transport system (30) and an irradiation unit (40) having at least one scanning magnet (100; 110), a dose detector (120) and at least one beam position monitor (130) installed in between said scanning magnet (100; 110) and said target volume (50), a controller (80) comprising means for calculating for any said prescribed irradiation point corresponding nominal magnetic settings of the scanning magnet such that a beam (90) is pointing to said prescribed irradiation point when corresponding magnetic settings are applied, and means for calculating a corresponding expected position at said beam position monitor (130), characterized in that said controller (80) further comprises: a) means for selecting a tuning reference point from said series of prescribed irradiation points; b) means for specifying a prescribed tuning dose to be given to said selected tuning reference point, said prescribed tuning dose being equal or smaller than said prescribed dose at said selected tuning reference point; c) means for comparing a beam position provided by the beam position monitor (130) and the expected position at said beam position monitor (130) for said selected tuning reference point; d) means for computing a first correction to be applied to said nominal magnetic settings of the scanning magnet (100; 110) in order to align the beam position provided by the beam position monitor to the expected position at said beam position monitor (130) for said selected tuning reference point; e) means for correcting the nominal magnetic settings of the scanning magnet for all said prescribed irradiation points according to said first correction. ### Claim 2 (depends on 1) The charged particle irradiation device (10) according to claim 1 wherein the means for selecting a tuning reference point are adapted to select a tuning reference point among the irradiation points (140) with the highest prescribed dose. ### Claim 3 (depends on 1) The charged particle irradiation device (10) according to claim 1 wherein the means for selecting a tuning reference point are adapted to select a tuning reference point in the center of a convex area of irradiation points (140) having a prescribed dose above a threshold. ### Claim 4 (depends on 1) The charged particle irradiation device (10) according to claim 1 wherein the means for selecting a tuning reference point are adapted to select a tuning reference point at random in a convex area of irradiation points (140) having a prescribed dose above a threshold. ### Claim 5 The charged particle irradiation device (10) according to any of preceding claims wherein the means for specifying a prescribed tuning dose are adapted to specify a prescribed tuning dose smaller than one tenth of the prescribed dose for the selected tuning reference point. ### Claim 6 (depends on 5) The charged particle irradiation device (10) according to claim 5 wherein the means for specifying a prescribed tuning dose are adapted to specify a prescribed tuning dose smaller than one hundredth of the prescribed dose for the selected tuning reference point. ### Claim 7 (depends on 6) The charged particle irradiation device (10) according to claim 6 wherein said controller (80) further comprises means for subtracting said prescribed tuning dose from the prescribed dose for said selected tuning reference point or for the nearest irradiation point. ### Claim 8 (depends on 5) The charged particle irradiation device (10) according to claim 5 wherein said controller (80) further comprises means for subtracting said prescribed tuning dose from the prescribed dose for said selected tuning reference point or for the nearest irradiation point. ### Claim 9 A method for tuning the delivery of a charged particle beam (90) in a charged particle irradiation device (10) for irradiating a target volume (50), adapted for receiving a treatment plan (70) defining a series of prescribed irradiation points (140) having each a prescribed dose to be delivered, comprising an accelerator (20), a beam transport system (30) and an irradiation unit (40) having at least one scanning magnet (100; 110), a dose detector (120) and at least one beam position monitor (130) installed in between said scanning magnet (100; 110) and said target volume (50), a controller (80) comprising means for calculating for any of said prescribed irradiation points (140) corresponding nominal magnetic settings of the scanning magnet (100; 110) such that the beam is pointing to said prescribed irradiation point (140) when corresponding magnetic settings are applied, and means for calculating an expected position at said beam position monitor, characterized in that it comprises the steps of: a) selecting a tuning reference point from said series of prescribed irradiation points (140); b) specifying a prescribed tuning dose to be given to said selected tuning reference point, said prescribed tuning dose being equal or smaller than said prescribed dose at said selected tuning reference point; c) comparing a beam position provided by the beam position monitor (130) and the expected position at said beam position monitor (130) for said selected tuning reference point; d) computing a first correction to be applied to said nominal magnetic settings of the scanning magnet (100; 110) in order to align the beam position provided by the beam position monitor (130) to the expected position at said beam position monitor (130) for said selected tuning reference point; e) correcting the nominal magnetic settings of the scanning magnet for all said prescribed irradiation points according to said first correction. ### Claim 10 (depends on 9) The method according to claim 9 wherein the step of selecting a tuning reference point selects a tuning reference point among the irradiation points (140) with the highest prescribed dose. ### Claim 11 (depends on 9) The method according to claim 9 wherein the step of selecting a tuning reference point selects a tuning reference point in the center of a convex area of irradiation points (140) having a prescribed dose above a threshold. ### Claim 12 (depends on 9) The method according to claim 9 wherein the step of selecting a tuning reference point selects a tuning reference point at random in a convex area of irradiation points (140) having a prescribed dose above a threshold. ### Claim 13 (depends on 9, 10, 11, 12) The method according to any of claims 9 to 12 wherein the step of specifying a prescribed tuning dose specifies a prescribed tuning dose smaller than one tenth of the prescribed dose for the selected tuning reference point. ### Claim 14 (depends on 13) The method according to claim 13 wherein the step of specifying a prescribed tuning dose specifies a prescribed tuning dose smaller than one hundredth of the prescribed dose for the selected tuning reference point. ### Claim 15 (depends on 14) The method according to claim 14 further comprising the step of subtracting said prescribed tuning dose from the prescribed dose for said selected tuning reference point or for the nearest irradiation point. ### Claim 16 (depends on 13) The method according to claim 13 further comprising the step of subtracting said prescribed tuning dose from the prescribed dose for said selected tuning reference point or for the nearest irradiation point.