# US 8,541,603 B2 · Substituted cyclopentanes or cyclopentanones as therapeutic agents

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- Number: US 8,541,603 B2
- Document ID: US8541603B2
- Status: Granted
- Kind: B2
- Application number: 12/992,229
- Filed: 2009-05-13
- Published: 2011-08-04
- Granted: 2013-09-24
- Earliest claimed: 2008-05-27
- Assignees: Allergan, Inc.
- Applicants: David W. Old; Todd S. Gac; Vinh X. Ngo
- Inventors: David W. Old; Todd S. Gac; Vinh X. Ngo
- Web page: https://patentgrep.com/patent/US8541603B2

## CPC

- C07D 295/088: to an acyclic saturated chain
- A61P 17/14: for baldness or alopecia
- A61P 27/06: Antiglaucoma agents or miotics
- C07C 405/00: Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins {; Analogues or derivatives thereof}
- C07C 2601/08: the ring being saturated
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

Therapeutic compounds, methods, and compositions are disclosed herein for treating glaucoma and baldness in mammals. The specific compounds are described herein and are modified prostaglandin derivates.

## Claims

### Claim 1

A compound having a formula selected from:
wherein Y is
or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

The compound of claim 1 according to the formula
or a pharmaceutically acceptable salt thereof.

### Claim 3 (depends on 1)

The compound of claim 1 according to the formula
or a pharmaceutically acceptable salt thereof.

### Claim 4 (depends on 1)

The compound of claim 1 according to the formula
or a pharmaceutically acceptable salt thereof.

### Claim 5 (depends on 1)

The compound of claim 1 according to the formula
or a pharmaceutically acceptable salt thereof.

### Claim 6 (depends on 1)

The compound of claim 1 according to the formula
or a pharmaceutically acceptable salt thereof.

### Claim 7 (depends on 1)

The compound of claim 1 according to the formula
or a pharmaceutically acceptable salt thereof.

### Claim 8 (depends on 1)

The compound of claim 1 according to the formula
or a pharmaceutically acceptable salt thereof.

### Claim 9 (depends on 1)

The compound of claim 1 according to the formula
or a pharmaceutically acceptable salt thereof.

### Claim 10 (depends on 1)

The compound of claim 1 according to the formula
or a pharmaceutically acceptable salt thereof.

### Claim 11 (depends on 1)

The compound of claim 1 according to the formula
or a pharmaceutically acceptable salt thereof.

### Claim 12 (depends on 1)

The compound of claim 1 according to the formula
or a pharmaceutically acceptable salt thereof.

### Claim 13 (depends on 1)

The compound of claim 1 according to the formula
or a pharmaceutically acceptable salt thereof.

### Claim 14 (depends on 1)

The compound of claim 1 according to the formula
or a pharmaceutically acceptable salt thereof.

### Claim 15 (depends on 1)

The compound of claim 1 according to the formula
or a pharmaceutically acceptable salt thereof.

### Claim 16 (depends on 1)

The compound of claim 1 according to the formula
or a pharmaceutically acceptable salt thereof.

### Claim 17 (depends on 1)

The compound of claim 1 according to the formula
or a pharmaceutically acceptable salt thereof.

### Claim 18 (depends on 1)

The compound of claim 1 according to the formula
or a pharmaceutically acceptable salt thereof.

### Claim 19 (depends on 1)

The compound of claim 1 according to the formula
or a pharmaceutically acceptable salt thereof.

### Claim 20 (depends on 1)

The compound of claim 1 according to the formula
or a pharmaceutically acceptable salt thereof.

### Claim 21 (depends on 1)

A method of treating baldness comprising administering to a subject in need thereof a therapeutically effective amount of a compound of claim 1.