# US 8,541,588 B2 · Sulfonamide derivatives

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- Number: US 8,541,588 B2
- Document ID: US8541588B2
- Status: Granted
- Kind: B2
- Application number: 13/400,356
- Filed: 2012-02-20
- Published: 2012-06-14
- Granted: 2013-09-24
- Earliest claimed: 2009-01-12
- Assignees: Pfizer Inc.; Icagen, Inc.
- Applicants: Serge Beaudoin; Michael Christopher Laufersweiler; Christopher John Markworth; Brian Edward Marron; David Simon Millan; David James Rawson; Steven Michael Reister; Kosuke Sasaki; Robert Ian Storer; Paul Anthony Stupple; Nigel Alan Swain; Christopher William West; Shulan Zhou
- Inventors: Serge Beaudoin; Michael Christopher Laufersweiler; Christopher John Markworth; Brian Edward Marron; David Simon Millan; David James Rawson; Steven Michael Reister; Kosuke Sasaki; Robert Ian Storer; Paul Anthony Stupple; Nigel Alan Swain; Christopher William West; Shulan Zhou
- Web page: https://patentgrep.com/patent/US8541588B2

## CPC

- C07D 417/12: linked by a chain containing hetero atoms as chain links
- A61K 31/427: not condensed and containing further heterocyclic rings
- A61K 31/433: Thidiazoles
- A61K 31/4439: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole (nicotine A61K31/465)
- A61K 31/454: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A61K 31/4545: containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A61K 31/496: Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A61K 31/501: not condensed and containing further heterocyclic rings
- A61K 31/506: not condensed and containing further heterocyclic rings
- A61K 31/675: having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61P 25/04: Centrally acting analgesics, e.g. opioids
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 263/50: Benzene-sulfonamido oxazoles
- C07D 275/03: with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D 277/18: Nitrogen atoms
- C07D 285/08: 1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
- C07D 401/12: linked by a chain containing hetero atoms as chain links
- C07D 413/12: linked by a chain containing hetero atoms as chain links
- C07D 417/14: containing three or more hetero rings
- C07F 9/6539: Five-membered rings
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)

## Abstract

The present invention relates to compounds of the formula and pharmaceutically acceptable salts, solvates or tautomers thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds, and the uses of such compounds, in particular for the treatment of pain.

## Claims

### Claim 1

A compound of the formula (I):
wherein
Z is Het2, optionally substituted on a ring carbon atom with one or more substituents selected from the group consisting of halo, cyano, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy, halo(C1-C4)alkoxy, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C4)alkyl, (C1-C4)alkyl-S—, amino, (C1-C4)alkylamino, di(C1-C4)alkylamino, amino(C1-C4)alkyl, (C1-C4)alkylamino(C1-C4)alkyl, and di[(C1-C4)alkyl]amino(C1-C4)alkyl; and/or Het2 is optionally substituted on a ring nitrogen atom with (C1-C4)alkyl, halo(C1-C4)alkyl and (C3-C8)cycloalkyl; with the proviso that Z is not tetrazolyl;
Y1, Y2, Y3 and Y4 are each independently CH, CR1 or N, provided that no more than two of Y1, Y2, Y3 and Y4 are N;
each R1 is independently selected from the group consisting of halo, cyano, amino, hydroxy, (C1-C4)alkyl, halo(C1-C4)alkyl, hydroxy(C1-C4)alkyl, (C1-C4)alkoxy, halo(C1-C4)alkoxy, (C1-C4)alkoxy(C1-C4)alkyl, —C(O)H, —C(O)(C1-C4)alkyl, and —C(O)N(R2)2;
each R2 is independently hydrogen, (C1-C4)alkyl, halo(C1-C4)alkyl, hydroxy(C1-C4)alkyl, or (C3-C6)cycloalkyl; or, where a nitrogen is substituted with two R2 groups, each independently selected from (C1-C4)alkyl, halo(C1-C4)alkyl, or hydroxy(C1-C4)alkyl, they may be taken together with the N atom to which they are attached to form a 4- to 6-membered ring which, when so formed, may therefore optionally be substituted with hydrogen, alkyl, halo, hydroxy, hydroxyalkyl or haloalkyl;
B is phenyl or Het2, wherein, when B is Het2 it is attached to the oxy linker at a ring carbon atom, and wherein B is optionally further substituted on a ring carbon atom with one or more substituents selected from the group consisting of halo, cyano, hydroxy, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy, halo(C1-C4)alkoxy, cyano(C1-C4)alkyl, amino, (C1-C4)alkylamino, di(C1-C4)alkylamino, amino(C1-C4)alkyl, (C1-C4)alkylamino(C1-C4)alkyl, di[(C1-C4)alkyl]amino(C1-C4)alkyl, trifluoromethylthio, hydroxy(C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkyl, —C(O)R2, —C(O)OR2, —OC(O)R2, —C(O)—N(R2)2, —CH2—C(O)R2, —CH2—C(O)OR2, —CH2—OC(O)R2, —CH2—C(O)—N(R2)2, S(O)2R2, S(O)2N(R2)2, (C3-C8)cycloalkyl, and (C3-C8)cycloalkyl(C1-C4)alkyl; and/or
Het2 is optionally substituted on a ring nitrogen atom with a substituent selected from the group consisting of (C1-C4)alkyl, halo(C1-C4)alkyl, hydroxy(C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkyl, amino(C1-C4)alkyl, (C1-C4)alkylamino(C1-C4)alkyl, di[(C1-C4)alkyl]amino(C1-C4)alkyl, —CH2—C(O)R2, —CH2—C(O)OR2, —CH2—C(O)—N(R2)2, S(O)2R2, and S(O)2N(R2)2;
X is absent, —O—, methylene, ethylene, methylene-O—, or —O-methylene;
C is (C3-C8)cycloalkyl, Het1, phenyl, or Het2, each optionally substituted on a ring carbon atom with one or more substituents selected from the group consisting of halo, cyano, hydroxy, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy, halo(C1-C4)alkoxy, N(R2)2, (R2)2N(C1-C4)alkyl, trifluoromethylthio, hydroxy(C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkyl, —C(O)R2, —C(O)OR2, —OC(O)R2, —C(O)—N(R2)2, —CH2—C(O)R2, —CH2—C(O)OR2, —CH2—OC(O)R2, —CH2—C(O)—N(R2)2, S(O)2R2, S(O)2N(R2)2, (C3-C8)cycloalkyl(C1-C4)alkyl, (C3-C8)cycloalkoxy, (C3-C8)cycloalkylamino, (C3-C8)cycloalkylamino(C1-C4)alkyl, (C3-C8)cycloalkyl(C1-C4)alkylamino, (C3-C8)cycloalkyl(C1-C4)alkylamino(C1-C4)alkyl, (C3-C8)cycloalkyl(C1-C4)alkoxy and D; and/or
Het2 is optionally substituted on a ring nitrogen atom with a substituent selected from the group consisting of hydroxy, (C1-C4)alkyl, halo(C1-C4)alkyl, amino(C1-C4)alkyl, (C1-C4)alkylamino(C1-C4)alkyl, di[(C1-C4)alkyl]amino(C1-C4)alkyl, hydroxy(C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkyl, —C(O)R2, —C(O)OR2, —CH2—C(O)R2, —CH2—C(O)OR2, —CH2—C(O)—N(R2)2, S(O)2R2, and S(O)2N(R2)2 and D;
D is phenyl, benzyl, (C3-C8)cycloalkyl, or Het1, each optionally substituted on a carbon atom with one or more substituents independently selected from the group consisting of halo, cyano, hydroxy, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy, halo(C1-C4)alkoxy, amino, (C1-C4)alkylamino, di(C1-C4)alkylamino, amino(C1-C4)alkyl, (C1-C4)alkylamino(C1-C4)alkyl, di[(C1-C4)alkyl]amino(C1-C4)alkyl, trifluoromethylthio, hydroxy(C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkyl, —C(O)R2, —C(O)OR2, —OC(O)R2, —C(O)—N(R2)2, —CH2—C(O)R2, —CH2—C(O)OR2, —CH2—OC(O)R2, —CH2—C(O)—N(R2)2, S(O)2R2, and S(O)2N(R2)2;
Het1 is a 3- to 8-membered, saturated or partially unsaturated monocyclic heterocyclic group comprising one or two or three ring members selected from —NR3—, —O—, —C(O)— and —S(O)p—;
R3 is either the point of attachment to X or C to give
or R3 is selected from the group consisting of hydrogen, (C1-C4)alkyl, halo(C1-C4)alkyl, hydroxy(C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkyl, —C(O)(C1-C4)alkyl, —C(O)O(C1-C4)alkyl, —CH2—C(O)O(C1-C4)alkyl, —CH2—C(O)—N((C1-C4)alkyl)2, S(O)2R2, S(O)2N(R2)2 and (C3-C8)cycloalkyl;
p is 0, 1 or 2; and
Het2 is a 5- or 6-membered aromatic heterocyclic group comprising either (a) 1 to 4 nitrogen atoms, (b) one oxygen or one sulphur atom or (c) 1 oxygen atom or 1 sulphur atom and 1 or 2 nitrogen atoms;
or a tautomer thereof, or a pharmaceutically acceptable salt of the compound of formula (I), or its tautomer;
with the proviso that the compound of formula (I) is not the following specific compound:

### Claim 2 (depends on 1)

A compound of formula (I), or a pharmaceutically acceptable salt, or tautomer thereof, as claimed in claim 1, wherein Z is not isoxazolyl.

### Claim 3 (depends on 1)

A compound of formula (I), or a pharmaceutically acceptable salt, or tautomer thereof, as claimed in claim 1, wherein Z is selected from the group consisting of 2-thiazolyl, 4-thiazolyl, 1-thia-3,4-diazolyl, 1-thia-2,4-diazolyl, pyridinyl, pyrazinyl, pyridazinyl, and pyrimidinyl.

### Claim 4 (depends on 1)

A compound of formula (I), or a pharmaceutically acceptable salt, or tautomer thereof, as claimed in claim 1, wherein Y1 is CR1, and Y2, Y3 and Y4 are each CH; or Y1 and Y3 are CR1 and Y2 and Y4 are CH.

### Claim 5 (depends on 4)

A compound of formula (I), or a pharmaceutically acceptable salt, or tautomer thereof, as claimed in claim 4, wherein each R1 is independently selected from halo; cyano; (C1-C4)alkyl; halo(C1-C4)alkyl; (C1-C4)alkoxy; and —C(O)NH2.

### Claim 6 (depends on 1)

A compound of formula (I), or a pharmaceutically acceptable salt, or tautomer thereof, as claimed in claim 1, wherein B is phenyl.

### Claim 7 (depends on 6)

A compound of formula (I), or a pharmaceutically acceptable salt, or tautomer thereof, as claimed in claim 6, wherein B is unsubstituted, or is substituted on a ring carbon with one or two substituents independently selected from the group consisting of halo; halo(C1-C4)alkyl; or halo(C1-C4)alkoxy.

### Claim 8 (depends on 1)

A compound of formula (I), or a pharmaceutically acceptable salt, or tautomer thereof, as claimed in claim 1, wherein C at the atom where it attaches to X, or directly to ring B if X is absent, is not further substituted except that such an atom may be substituted by hydrogen if chemically possible.

### Claim 9 (depends on 1)

A compound of formula (I), or a pharmaceutically acceptable salt, or tautomer thereof, as claimed in claim 1, wherein C is selected from the group consisting of pyrazolyl; pyridinyl; pyridazinyl; pyrimidinyl; azetidinyl; piperidinyl; or tetrahydropyranyl.

### Claim 10 (depends on 1)

A compound of formula (I), or a pharmaceutically acceptable salt, or tautomer thereof, as claimed in claim 1, wherein X is absent.

### Claim 11 (depends on 1)

A compound of formula (I), or a pharmaceutically acceptable salt, or tautomer thereof, as claimed in claim 1, which has the formula (Ib):
wherein Ra is independently selected from the group consisting of halo, cyano, hydroxy, (C1-C4)alkyl, halo(C1-C4)alkyl, (C1-C4)alkoxy, halo(C1-C4)alkoxy, cyano(C1-C4)alkyl, amino, (C1-C4)alkylamino, di(C1-C4)alkylamino, amino(C1-C4)alkyl, (C1-C4)alkylamino(C1-C4)alkyl, di[(C1-C4)alkyl]amino(C1-C4)alkyl, trifluoromethylthio, hydroxy(C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkyl, —C(O)R2, —C(O)OR2, —OC(O)R2, —C(O)—N(R2)2, —CH2—C(O)R2, —CH2—C(O)OR2, —CH2—OC(O)R2, —CH2—C(O)—N(R2)2, S(O)2R2, S(O)2N(R2)2, (C3-C8)cycloalkyl, and (C3-C8)cycloalkyl(C1-C4)alkyl;
and
n is 0, 1 or 2.

### Claim 12 (depends on 1)

A compound of formula (I), or a pharmaceutically acceptable salt, or tautomer thereof, as claimed in claim 1, selected from the group consisting of:
4-[2-(6-Aminopyridin-3-yl)-4-fluorophenoxy]-N-(5-chloro-1,3-thiazol-2-yl)-3-cyanobenzenesulfonamide;
5-chloro-4-(4-chloro-2-piperidin-4-ylphenoxy)-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide;
4-[4-Chloro-2-(1H-pyrazol-4-yl)phenoxy]-3-cyano-N-1,3-thiazol-2-ylbenzenesulfonamide;
3-cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethoxy)phenoxy]-N-1,3-thiazol-2-ylbenzenesulfonamide;
4-(2-azetidin-3-yl-4-chlorophenoxy)-5-chloro-N-(5-chloro-1,3-thiazol-2-yl)-2-fluorobenzenesulfonamide;
N-(5-Chloro-1,3-thiazol-2-yl)-3-cyano-4-[4-fluoro-2-(1H-pyrazol-4-yl)phenoxy]benzenesulfonamide;
N-(5-Chloro-1,3-thiazol-2-yl)-3-cyano-4-[4-chloro-2-(1H-pyrazol-4-yl)phenoxy]benzenesulfonamide;
4-[2-(2-aminopyridin-4-yl)-4-chlorophenoxy]-2,5-difluoro-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide;
2,5-difluoro-4-[2-(1H-pyrazol-5-yl)-4-(trifluoromethyl)phenoxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
2,5-difluoro-4-[2-(1H-pyrazol-4-yl)-4-(trifluoromethyl)phenoxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
4-(4-chloro-2-(1H-pyrazol-4-yl)phenoxy)-3-cyano-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide;
4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-3-cyano-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
3-cyano-4-[2-(1H-pyrazol-5-yl)-4-(trifluoromethoxy)phenoxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
3-cyano-4-[2-(1-methyl-1H-pyrazol-5-yl)-4-(trifluoromethoxy)phenoxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
5-chloro-4-(4-chloro-2-piperidin-4-ylphenoxy)-2-fluoro-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
3-cyano-4-[2-(5-methyl-1H-pyrazol-4-yl)-4-(trifluoromethyl)phenoxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
4-{2-[2-(aminomethyl)pyridin-4-yl]-4-chlorophenoxy}-5-chloro-2-fluoro-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
3-Cyano-4-[2-(tetrahydro-2H-pyran-4-yl)-4-(trifluoromethyl)phenoxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
5-Chloro-2-fluoro-N-(5-fluoropyridin-2-yl)-4-[2-piperidin-4-yl-4-(trifluoromethyl)phenoxy]benzenesulfonamide;
4-[2-(1-azetidin-3-yl-1H-pyrazol-5-yl)-4-chlorophenoxy]-2,5-difluoro-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
3-cyano-4-[2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide;
4-[4-chloro-5-fluoro-2-(1H-pyrazol-4-yl)phenoxy]-3-cyano-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
2,5-difluoro-4-[2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
5-Chloro-2-fluoro-4-{4-fluoro-2-[1-(1-methylazetidin-3-yl)-1H-pyrazol-5-yl]phenoxy}-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
5-Chloro-2-fluoro-4-{4-fluoro-2-[1-(1-methylazetidin-3-yl)-1H-pyrazol-5-yl]phenoxy}-N-1,3-thiazol-4-ylbenzenesulfonamide;
4-[2-(1-Azetidin-3-yl-1H-pyrazol-5-yl)-4-fluorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide;
4-[2-(1-azetidin-3-yl-1H-pyrazol-5-yl)-4-chlorophenoxy]-3-cyano-N-1,3-thiazol-4-ylbenzenesulfonamide;
4-[2-(1-azetidin-3-yl-1H-pyrazol-5-yl)-4-fluorophenoxy]-5-chloro-2-fluoro-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
4-{4-Chloro-2-[1-(1-methylazetidin-3-yl)-1H-pyrazol-5-yl]phenoxy}-2,5-difluoro-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
4-[2-(2-aminopyridin-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-pyrimidin-4-ylbenzenesulfonamide;
5-chloro-4-[4-chloro-2-(1-methyl-1H-pyrazol-5-yl)phenoxy]-2-fluoro-N-pyrimidin-4-ylbenzenesulfonamide;
4-[2-(2-aminopyridin-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide;
3-cyano-4-[2-pyridazin-4-yl-4-(trifluoromethoxy)phenoxy]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
4-{4-Chloro-2-[2-(dimethylamino)pyridin-4-yl]phenoxy}-3-cyano-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
2,5-Difluoro-4-{2-[1-(1-methylazetidin-3-yl)-1H-pyrazol-5-yl]-4-(trifluoromethyl)phenoxy}-N-1,3-thiazol-4-ylbenzenesulfonamide;
4-{4-Chloro-2-[1-(1-ethylazetidin-3-yl)-1H-pyrazol-5-yl]phenoxy}-3-cyano-N-1,3-thiazol-4-ylbenzenesulfonamide;
4-{4-Chloro-2-[2-(cyclobutyloxy)pyridin-4-yl]phenoxy}-3-cyano-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
4-{4-Chloro-2-[2-(dimethylamino)pyridin-4-yl]phenoxy}-3-cyano-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
5-chloro-2-fluoro-4-[2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide;
4-[2-(3-amino-1H-pyrazol-4-yl)-4-(trifluoromethyl)phenoxy]-5-chloro-2-fluoro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide;
4-[2-(3-amino-1H-pyrazol-4-yl)-4-(trifluoromethyl)phenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide;
4-[4-Chloro-2-(2-piperazin-1-ylpyrimidin-4-yl)phenoxy]-3-cyano-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
4-[2-(2-aminopyridin-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-pyridazin-3-ylbenzenesulfonamide;
4-{2-[2-(Azetidin-1-ylmethyl)pyridin-4-yl]-4-chlorophenoxy}-2,5-difluoro-N-1,3-thiazol-4-ylbenzenesulfonamide;
3-Cyano-4-{2-[1-(1-ethylazetidin-3-yl)-1H-pyrazol-5-yl]-4-(trifluoromethyl)phenoxy}-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide;
5-Chloro-2-fluoro-4-[5-fluoro-2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide;
3-Cyano-4-[5-fluoro-2-pyridazin-4-yl-4-(trifluoromethyl)phenoxy]-N-1,2,4-thiodiazol-5-ylbenzenesulfonamide;
4-[2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-pyrimidin-4-ylbenzenesulfonamide;
2-fluoro-5-methyl-4-[2-pyridazin-4-yl-4-(trifluoromethoxy)phenoxy]-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide;
4-[2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-pyridazin-3-ylbenzenesulfonamide, and
4-[2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-pyrimidin-2-ylbenzenesulfonamide.

### Claim 13 (depends on 1)

A pharmaceutical composition comprising a compound of formula (I), or a pharmaceutically acceptable salt, or tautomer thereof, as claimed in claim 1, and one or more pharmaceutically acceptable excipients.

### Claim 14 (depends on 13)

A pharmaceutical composition as claimed in claim 13 comprising one or more additional therapeutic agents.

### Claim 15 (depends on 1)

A method of treating pain in a mammal comprising administering to a mammal requiring such treatment an effective amount of a compound of the formula (I), or a pharmaceutically acceptable salt, or tautomer thereof, according to claim 1.

### Claim 16

4-[2-(2-Aminopyridin-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-pyridazin-3-ylbenzenesulfonamide; or a pharmaceutically acceptable salt or tautomer thereof.

### Claim 17

4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-pyrimidin-2-ylbenzenesulfonamide; or a pharmaceutically acceptable salt or tautomer thereof.

### Claim 18 (depends on 15)

A method of treating pain according to claim 15 in which said pain is selected from the group consisting of neuropathic pain, nociceptive pain and inflammatory pain.