# US 8,541,572 B2 · Compounds for the treatment of inflammatory disorders

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- Number: US 8,541,572 B2
- Document ID: US8541572B2
- Status: Granted
- Kind: B2
- Application number: 13/127,952
- Filed: 2009-11-09
- Published: 2012-01-12
- Granted: 2013-09-24
- Earliest claimed: 2008-11-10
- Assignees: Merck Sharp & Dohme Corp.
- Applicants: Joseph A. Kozlowski; Wensheng Yu; Michael K. C. Wong; Seong Heon Kim; Ling Tong; Brian J. Lavey; Bandarpalle B. Shankar; De-Yi Yang; Robert Feltz; Aneta Maria Kosinski; Guowei Zhou; Razia K. Rizvi; Chaoyang Dai; Luke Fire; Vinay Girijavallabhan; Dansu Li; Janeta Popovici-Muller; Judson E. Richard; Kristin E. Rosner; M. Arshad Siddiqui; Liping Yang
- Inventors: Joseph A. Kozlowski; Wensheng Yu; Michael K. C. Wong; Seong Heon Kim; Ling Tong; Brian J. Lavey; Bandarpalle B. Shankar; De-Yi Yang; Robert Feltz; Aneta Maria Kosinski; Guowei Zhou; Razia K. Rizvi; Chaoyang Dai; Luke Fire; Vinay Girijavallabhan; Dansu Li; Janeta Popovici-Muller; Judson E. Richard; Kristin E. Rosner; M. Arshad Siddiqui; Liping Yang
- Web page: https://patentgrep.com/patent/US8541572B2

## CPC

- C07D 403/14: containing three or more hetero rings
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 17/06: Antipsoriatics
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 27/06: Antiglaucoma agents or miotics
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/04: Antibacterial agents
- A61P 31/18: for HIV
- A61P 35/00: Antineoplastic agents
- A61P 35/04: specific for metastasis
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF—or combinations thereof.

## Claims

### Claim 1

A compound selected from the group consisting of
and a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

The compound of claim 1, selected from the group consisting of:
and a pharmaceutically acceptable salt thereof.

### Claim 3 (depends on 2)

The compound of claim 2, selected from the group consisting of:
and a pharmaceutically acceptable salt thereof.

### Claim 4 (depends on 1)

A pharmaceutical composition comprising the compound of claim 1 or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable carrier.