# US 8,541,553 B2 · Antibodies specific for the melanoma-associated endogenous retrovirus (MERV) envelope glycoprotein

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- Number: US 8,541,553 B2
- Document ID: US8541553B2
- Status: Granted
- Kind: B2
- Application number: 12/601,780
- Filed: 2008-05-23
- Published: 2010-06-03
- Granted: 2013-09-24
- Earliest claimed: 2007-05-24
- Assignees: Baxter Healthcare S.A.
- Applicants: Johannes Humer; Bernd Mayer; Thomas Muster; Andrea Waltenberger
- Inventors: Johannes Humer; Bernd Mayer; Thomas Muster; Andrea Waltenberger
- Web page: https://patentgrep.com/patent/US8541553B2

## CPC

- C07K 16/112: Retroviridae (F), e.g. leukemia viruses
- A61P 35/00: Antineoplastic agents
- C07K 16/3053: {Skin, nerves, brain}
- A61K 2039/505: {comprising antibodies}
- C07K 2317/34: Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
- C07K 2317/73: Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K 2317/732: Antibody-dependent cellular cytotoxicity [ADCC]
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention provides antibodies, or fragments thereof, for isolating and/or identifying epitopes of an endogenous retrovirus, preferably of a melanoma associated endogenous retrovirus, and hybridoma cells producing said antibodies. The antibodies are useful especially for the treatment and diagnosis of cancer. Further, the present application covers diagnostic kits for the detection of cancer cells, especially of melanoma cells and methods for cancer diagnosis using said antibodies.

## Claims

### Claim 1

An antibody characterized in that it is produced by the hybridoma cell line having DSMZ accession number DSM ACC2879.

### Claim 2

A hybridoma cell line having DSMZ accession number DSM ACC2879.