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US 8,541,548 B2Granted
Compounds and methods for reversible modification of biologically active molecules
AssigneeArrowhead Madison Inc.
InventorDavid B. Rozema
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Abstract
The present invention is directed compounds for reversibly modification of biologically active molecules. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.
Claims10
An amine-reactive modifying agent represented by the structure consisting of:
- wherein R2 is a methyl group or ethyl group and R1 is or contains a group selected from the group consisting of:
- aldehyde, maleic anhydride, galactose, vitamin, biotin, and polyethylene glycol.
A pH labile compound represented by the structure consisting of:
- wherein
- R1 is or contains a group selected from the group consisting of:
- aldehyde, maleic anhydride, galactose, vitamin, biotin and polyethylene glycol;
- R2 is a methyl or ethyl group;
- and,
- R3 is any group.
3 more elements
Dependencies are inferred from the claim text.