Water-soluble strontium salts for use in treatment of cartilage and/or bone conditions
AssigneeOsteologix A/S
InventorsChristian Hansen, Henrik Nilsson, Stephan Christgau, Jens E. T. Andersen
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Abstract
Compounds and pharmaceutical compositions for use in the treatment and/or prophylaxis of cartilage and/or bone conditions and for methods of treating such condition. The compounds are salts of strontium that have a water-solubility of from about 1 g/l to about 100 g/l at room temperature, especially amino acid salts of strontium or dicarboxylic acid salts of strontium. Examples of novel water-soluble strontium salts are e.g. strontium glutamate and strontium alpha-ketoglutarate. The present invention also relates to an improved method for preparing the strontium salt of glutamic acid.
Claims58
A method for the treatment of a bone disease and/or condition resulting in a dysregulation of bone metabolism in a mammal in need thereof, the method comprising administering to the mammal a therapeutically effective amount of one or more strontium salts selected from the group consisting of strontium succinate, strontium glutamate, strontium ketoglutarate, strontium maleate, and strontium pyruvate, wherein the bone disease and/or condition resulting in a dysregulation of bone metabolism is osteoporosis or osteopenia.
A method for the treatment of a bone disease and/or condition resulting in a dysregulation of bone metabolism in a subject in need thereof, the method comprising administering to said subject one or more strontium salts, wherein the one or more strontium salts provide a maximum plasma concentration of strontium from about 4 hours to about 24 hours after administration to said subject;
- wherein the one or more strontium salts are selected from the group consisting of strontium succinate, strontium glutamate, strontium ketoglutarate, strontium maleate, and strontium pyruvate;
- and wherein the bone disease and/or condition resulting in a dysregulation of bone metabolism is osteoporosis or osteopenia.
A method for the treatment of a bone disease and/or condition resulting in a dysregulation of bone metabolism in a subject, the method comprising administering to said subject one or more strontium salts, wherein the one or more strontium salts provides a maximum plasma concentration of strontium from about 5.5 hours to about 24 hours after administration to said subject;
- wherein the one or more strontium salts are selected from the group consisting of strontium succinate, strontium glutamate, strontium ketoglutarate, strontium maleate, and strontium pyruvate;
- and wherein the bone disease and/or condition resulting in a dysregulation of bone metabolism is osteoporosis or osteopenia.
A method for the treatment of a bone disease and/or condition resulting in a dysregulation of bone metabolism in a subject, the method comprising administering to said subject one or more strontium salts to provide a steady state plasma concentration of from about 5 mg/L to about 50 mg/L of strontium alter repeated administration through steady state conditions in said subject;
- wherein the one or more strontium salts are selected from the group consisting of strontium succinate, strontium glutamate, strontium ketoglutarate, strontium maleate, and strontium pyruvate;
- and wherein the bone disease and/or condition resulting in a dysregulation of bone metabolism is osteoporosis or osteopenia.
Dependencies are inferred from the claim text.