# US 8,541,454 B2 · Antiseptic based on bispyridinium alkanes > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,541,454 B2 - Document ID: US8541454B2 - Status: Granted - Kind: B2 - Application number: 13/156,635 - Filed: 2011-06-09 - Published: 2012-01-05 - Granted: 2013-09-24 - Earliest claimed: 2010-07-02 - Assignees: L'Air Liquide, Societe Anonyme pour l'Etude et l'Exploitation des Procedes Georges Claude - Applicants: Sabine Behrends; Andreas Dettmann; Mona Golombiewski; Elke Kassens - Inventors: Sabine Behrends; Andreas Dettmann; Mona Golombiewski; Elke Kassens - Web page: https://patentgrep.com/patent/US8541454B2 ## CPC - A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)} - A01N 43/40: six-membered rings - A61K 31/4425: Pyridinium derivatives, e.g. pralidoxime, pyridostigmine - A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers - A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract An antimicrobially effective composition includes a) at least 0.15% by weight of bispyridinium alkane, b) at least 3.5% by weight of humectant and c) water. Upon dilution with water, the composition produces a solution with an osmolality of from 230 to 350 mOsmol/kg and is free from surfactant. It is used as an antiseptic and is suitable for use in a method for the disinfection of injured or uninjured skin of a human being or animal, preference being given to use in the case of newborns, in particular those born prematurely. ## Claims ### Claim 1 An antimicrobially effective composition comprising for 100% by weight: a) between 0.15% and 5% by weight of bispyridinium alkane, b) between 5% and 20% by weight of humectant and c) Water, where the composition: is free from surfactant and wherein the composition is free of aliphatic alcohol and aromatic alcohol. ### Claim 2 (depends on 1) The composition according to claim 1, wherein the composition is free from inorganic salts. ### Claim 3 (depends on 1) The composition according to claim 1, wherein the composition is free from antioxidant. ### Claim 4 (depends on 1) The composition according to claim 1, wherein component a) is octenidine dihydrochloride. ### Claim 5 (depends on 1) The composition according to claim 1, wherein the composition comprises 0.2 to 2.5% by weight of component a). ### Claim 6 (depends on 1) The composition according to claim 1, wherein the humectant is selected from the group of polyhydric alcohols selected from the group consisting of glycerol, 1,2-propylene glycol, sorbitol, glucose, fructose, glucuronic acid, lactose, lactic acid, lactates, lactulose, polyethylene glycols, sucrose, hyaluronic acid, xylitol, xylose and mixtures thereof. ### Claim 7 (depends on 6) The composition according to claim 6, wherein component b) is glycerol. ### Claim 8 (depends on 1) The composition according to claim 1, wherein the composition comprises 10 to 15% by weight of component b). ### Claim 9 (depends on 1) The composition according to claim 1, wherein the composition consists of the components: a) Octenidine dihydrochloride in an amount of from 0.25 to 1% by weight, b) Glycerol in an amount of from 11 to 13% by weight, and c) Water as the remainder. ### Claim 10 A method for the disinfection of injured or uninjured skin of a human being or animal, which comprises applying to the skin an effective amount of a solution comprising, for 100% by weight: a) 0.001% to 1% by weight of bispyridinium alkane, b) between 5% to 20% by weight of humectants, and c) water, where the solution: (i) has an osmolality of from 230 to 350 mOsmol/kg and (ii) is free from surfactant and wherein the composition is free of aliphatic alcohol and aromatic alcohol. ### Claim 11 (depends on 10) The method according to claim 10, characterized in that the disinfection method involves an ultrasound-associated wound treatment (UAW). ### Claim 12 (depends on 10) The method according to claim 10, wherein the injured or uninjured skin is that of a newborn human being or animal. ### Claim 13 (depends on 10) The method according to claim 10, wherein the injured or uninjured skin is that of a premature human being or animal.