# US 8,541,416 B2 · Method for treating a sleep disorder with a dosage form of a zopiclone or eszopiclone L-malate salt

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- Number: US 8,541,416 B2
- Document ID: US8541416B2
- Status: Granted
- Kind: B2
- Application number: 13/470,003
- Filed: 2012-05-11
- Published: 2012-08-30
- Granted: 2013-09-24
- Earliest claimed: 2007-12-19
- Assignees: Sunovion Pharmaceuticals Inc.
- Applicants: H. Scott Wilkinson; Richard Hsia; Tushar Misra; Kostas Saranteas; Patrick Mousaw
- Inventors: H. Scott Wilkinson; Richard Hsia; Tushar Misra; Kostas Saranteas; Patrick Mousaw
- Web page: https://patentgrep.com/patent/US8541416B2

## CPC

- C07D 487/04: Ortho-condensed systems
- A61P 25/20: Hypnotics; Sedatives
- C07C 59/245: containing hydroxy or O-metal groups
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

L-malate salts of (6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl) carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine) are provided.

## Claims

### Claim 1

A method for treating a sleep disorder in a subject comprising administering to a subject in need thereof a pharmaceutical dosage form comprising an L-malate salt of zopiclone and a pharmaceutically acceptable carrier, such that administration of the dosage form treats the sleep disorder.

### Claim 2

A method for treating a sleep disorder in a subject comprising administering to a subject in need thereof a pharmaceutical dosage form comprising an L-malate salt of eszopiclone and a pharmaceutically acceptable carrier, such that administration of the dosage form treats the sleep disorder.