# US 8,541,396 B2 · Morpholin-4-ium 4 methoxyphenyl (morpholino) phosphinodithioate (GYY4137) as a novel vasodilator agent

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 8,541,396 B2
- Document ID: US8541396B2
- Status: Granted
- Kind: B2
- Application number: 12/429,661
- Filed: 2009-04-24
- Published: 2010-10-28
- Granted: 2013-09-24
- Earliest claimed: 2009-04-24
- Assignees: National University of Singapore
- Applicants: Philip Keith Moore; Choon-Hong Tan; Ling Li; Yan Yi Guan
- Inventors: Philip Keith Moore; Choon-Hong Tan; Ling Li; Yan Yi Guan
- Web page: https://patentgrep.com/patent/US8541396B2

## CPC

- A61K 31/675: having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A61K 31/66: Phosphorus compounds
- A61K 31/662: Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The invention is directed to a method of administering hydrogen sulfide (H2S) slowly and sustainably to an individual in need thereof comprising administering an effective amount of a compound represented by the following structural formula: or a pharmaceutically acceptable salt thereof.

## Claims

### Claim 1

A method of providing hydrogen sulfide (H2S) slowly and sustainably to an individual in need thereof comprising administering an effective amount of
morpholin-4-ium 4 methoxyphenyl(morpholino) phosphinodithioate (GYY4137) or a pharmaceutically acceptable salt thereof.

### Claim 2

A method of treating inflammation in an individual in need thereof comprising administering an effective amount of
morpholin-4-ium 4 methoxyphenyl(morpholino) phosphinodithioate (GYY4137) or a pharmaceutically acceptable salt thereof.