Modulation of SMRT expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsSanjay K. Pandey, Sanjay Bhanot, Eric G. Marcusson, Susan M. Freier
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Abstract
Disclosed herein are compounds and methods for decreasing SMRT and treating metabolic and/or cardiovascular diseases in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to SMRT include obesity, diabetes, dyslipidemia, and hypothyroidism.
Claims37
A method of treating or ameliorating obesity, diabetes, dyslipidemia, hyperthyroidism, or a combination thereof in an animal diagnosed as having obesity, diabetes, dyslipidemia, hyperthyroidism, or a combination thereof, comprising administering to the animal a therapeutically effective amount of a silencing mediator of retinoid and thyroid hormone receptor (SMRT) inhibitor, wherein the SMRT inhibitor is a nucleic acid and the obesity, diabetes, dyslipidemia, hyperthyroidism, or combination thereof is treated or ameliorated in the animal.
A method of decreasing triglyceride levels, cholesterol levels, glucose levels, body weight, fat content, insulin resistance, or any combination thereof in a human comprising administering a silencing mediator of retinoid and thyroid hormone receptor (SMRT) inhibitor to the human diagnosed as being in need of decreasing triglyceride levels, cholesterol levels, glucose levels, body weight, fat content, insulin resistance, or any combination thereof, wherein the SMRT inhibitor is a nucleic acid, thereby decreasing triglyceride levels, cholesterol levels, glucose levels, body weight, fat content, insulin resistance, or any combination thereof in the human.
A method comprising identifying an animal having obesity, diabetes, dyslipidemia, hyperthyroidism, or a combination thereof, and administering to said animal a therapeutically effective amount of a composition comprising a modified oligonucleotide consisting of 12 to 30 linked nucleosides having a nucleobase sequence complementary to SEQ ID NO:
- 1, 2, or 3 as measured over the entirety of said modified oligonucleotide, wherein the modified oligonucleotide is capable of inhibiting silencing mediator of retinoid and thyroid hormone receptor (SMRT), thereby treating the obesity, diabetes, dyslipidemia, hyperthyroidism, or combination thereof.
Dependencies are inferred from the claim text.