# US 8,541,382 B2 · Cardiac glycoside analogs in combination with emodin for cancer therapy > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,541,382 B2 - Document ID: US8541382B2 - Status: Granted - Kind: B2 - Application number: 13/018,435 - Filed: 2011-02-01 - Published: 2012-05-17 - Granted: 2013-09-24 - Earliest claimed: 2010-11-13 - Assignees: Sirbal Ltd. - Applicants: Nadav Shraibom - Inventors: Nadav Shraibom - Web page: https://patentgrep.com/patent/US8541382B2 ## CPC - A61K 31/7048: having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin {, digitoxin or digoxin} - A61K 31/122: having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin - A61K 36/704: Polygonum, e.g. knotweed - A61K 36/708: Rheum (rhubarb) - A61K 36/72: Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree - A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca - A61P 35/00: Antineoplastic agents - A61P 35/02: specific for leukemia - A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract A method and medicine for treating leukemia or other cancer includes administering to a patient diagnosed with leukemia or other cancer a treatment regimen that includes periodic doses of a combination of emodin and digoxin. ## Claims ### Claim 1 A method of treating leukemia, melanoma, or colon, prostate or breast cancer comprising administering to a patient diagnosed with leukemia, melanoma, or colon, prostate or breast cancer a treatment regimen comprising the step of administering periodic doses of an effective amount of digoxin in combination with approximately 5 ug/ml or more of emodin. ### Claim 2 The method of 1, wherein the periodic doses comprise more than approximately 10 ug/ml of emodin. ### Claim 3 The method of 1, wherein the periodic doses comprise approximately 10 ug/ml emodin. ### Claim 4 The method of 1, wherein the periodic doses comprise more than approximately 0.05 ug/ml of digoxin. ### Claim 5 The method of 1, wherein the periodic doses comprise approximately 0.1 ug/ml digoxin. ### Claim 6 The method of 1, wherein the periodic doses comprise approximately 10 ug/ml of emodin and approximately 0.05 ug/ml or more of digoxin. ### Claim 7 The method of 1, wherein the periodic doses comprise approximately 10 ug/ml emodin and approximately 0.10 ug/ml digoxin. ### Claim 8 The method of 1, wherein the periodic doses comprise approximately 10 ug/ml or more of emodin and approximately 0.05 ug/ml or more of digoxin. ### Claim 9 The method of 1, wherein the periodic doses comprise between approximately 5 and 10 ug/ml of emodin and between approximately 0.05 and 0.1 ug/ml of digoxin. ### Claim 10 The method of 1, wherein the treatment regimen comprises twice daily doses. ### Claim 11 The method of 1, wherein the treatment regimen comprises daily doses. ### Claim 12 The method of 1, wherein the treatment regimen comprises multiple doses per week. ### Claim 13 The method of 1, comprising varying doses of each of the emodin and digoxin. ### Claim 14 A method of treating leukemia, melanoma, or colon, prostate or breast cancer comprising administering to a patient diagnosed with leukemia, melanoma, or colon, prostate or breast cancer a treatment regimen comprising the step of administering periodic doses of an effective amount of digoxin in combination with approximately 5 ug/ml or more of emodin or the step of administering an effective amount of digoxin in combination with approximately 5 ug/ml or more of emodin with DMSO. ### Claim 15 (depends on 14) The method of claim 14, comprising varying doses of each of the emodin and digoxin. ### Claim 16 (depends on 14) The method of claim 14, wherein the periodic doses 10 ug/ml or more of emodin. ### Claim 17 (depends on 14) The method of claim 14, wherein the periodic doses comprise approximately 10 ug/ml of emodin. ### Claim 18 (depends on 14) The method of claim 14, wherein the periodic doses comprise approximately 0.05 ug/ml or more of digoxin. ### Claim 19 (depends on 14) The method of claim 14, wherein the periodic doses comprise approximately 0.10 ug/ml digoxin. ### Claim 20 (depends on 14) The method of claim 14, wherein the periodic doses comprise approximately 10 ug/ml of emodin and approximately 0.05 ug/ml or more of digoxin. ### Claim 21 (depends on 14) The method of claim 14, wherein the periodic doses comprise approximately 10 ug/ml or more of emodin and approximately 0.10 ug/ml of digoxin. ### Claim 22 (depends on 14) The method of claim 14, wherein the periodic doses comprise approximately 10 ug/ml or more of emodin and approximately 0.05 ug/ml or more of digoxin. ### Claim 23 (depends on 14) The method of claim 14, wherein the periodic doses comprise between approximately 5 and 10 ug/ml of emodin and between approximately 0.05 and 0.1 ug/ml of digoxin. ### Claim 24 (depends on 14) The method of claim 14, wherein the treatment regimen comprises twice daily doses. ### Claim 25 The method of 1, wherein the treatment regimen comprises daily doses. ### Claim 26 The method of 1, wherein the treatment regimen comprises multiple doses per week. ### Claim 27 The method of 1, wherein the emodin has been extracted from rhubarb root. ### Claim 28 (depends on 14) The method of claim 14, wherein the emodin has been extracted from rhubarb root. ### Claim 29 The method of 1, wherein the emodin has been extracted from rhubarb, Buckthorn, and/or Japanese Knotweed. ### Claim 30 (depends on 14) The method of claim 14, wherein the emodin has been extracted from rhubarb, Buckthorn, and/or Japanese Knotweed. ### Claim 31 The method of 1, wherein the periodic doses comprise 1.0 ug/ml of digoxin. ### Claim 32 (depends on 31) The method of claim 31, wherein the periodic doses comprise 0.05 ug/ml or more of digoxin. ### Claim 33 (depends on 31) The method of claim 31, wherein the periodic doses comprise 0.1 ug/ml or more of digoxin. ### Claim 34 (depends on 14) The method of claim 14, wherein the periodic doses comprise approximately 1.0 ug/ml of digoxin. ### Claim 35 (depends on 34) The method of claim 34, wherein the periodic doses comprise 0.05 ug/ml or more of digoxin. ### Claim 36 (depends on 34) The method of claim 34, wherein the periodic doses comprise 0.1 ug/ml or more of digoxin. ### Claim 37 The method of 1, wherein the patient has been diagnosed with melanoma. ### Claim 38 (depends on 14) The method of claim 14, wherein the patient has been diagnosed with melanoma. ### Claim 39 The method of 1, wherein the patient has been diagnosed with breast cancer. ### Claim 40 (depends on 14) The method of claim 14, wherein the patient has been diagnosed with breast cancer.