# US 8,541,374 B2 · Use of a composition comprising a non-fermented rice peptidic hydrolyzate for stimulating hair growth

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- Number: US 8,541,374 B2
- Document ID: US8541374B2
- Status: Granted
- Kind: B2
- Application number: 13/505,488
- Filed: 2010-11-02
- Published: 2012-08-23
- Granted: 2013-09-24
- Earliest claimed: 2009-11-03
- Assignees: ISP Investments Inc.
- Applicants: Claude Dal Farra; Nouha Domloge; Jean-Marie Botto
- Inventors: Claude Dal Farra; Nouha Domloge; Jean-Marie Botto
- Web page: https://patentgrep.com/patent/US8541374B2

## CPC

- A61K 36/899: Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K 8/645: {Proteins of vegetable origin; Derivatives or degradation products thereof}
- A61P 17/14: for baldness or alopecia
- A61Q 5/00: Preparations for care of the hair
- A61Q 7/00: Preparations for affecting hair growth
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present invention relates to the use of a composition comprising at least one non-fermented rice peptidic hydrolyzate as an active agent for slowing down and limiting hair loss and/or stimulating hair growth. Said composition is also intended to protect the follicular adult stem cells as well as their specific microenvironment. In addition, the composition according to the invention combats the aging and particularly the photoaging of hair. Lastly, the present invention relates to several non-therapeutic treatment methods utilizing said composition.

## Claims

### Claim 1

A non-therapeutic method to slow down hair loss and stimulate hair growth, the method comprising:
Providing a composition comprising at least one non-fermented rice peptidic hydrolyzate coming from the hydrolysis of rice grain proteins from the Oryza sativa L rice species, as an active agent, wherein at least 70% of the peptidic nature compounds present in the hydrolyzate are peptides with a size of less than 6 kDa; and
applying the composition to a portion of the anatomy having hair follicles;
where the non-fermented rice peptidic hydrolyzate results in an increase in β-cantenin labelling of the hair follicles thereby indicating an increase in the differentiation and growth of the hair follicles.

### Claim 2

A non-therapeutic method to protect follicular adult stem cells as well as their specific microenvironment, the method comprising:
providing a composition comprising at least one non-fermented rice peptidic hydrolyzate coming from the hydrolysis of rice grain proteins from the Oryza Sativa L rice species, as an active agent, wherein at least 70% of the peptidic nature compounds present in the hydrolyzate are peptides with a size of less than 6 kDa; and
applying the composition to the scalp zone;
wherein the composition protects follicular adult stem cells.

### Claim 3 (depends on 2)

The method of claim 2, wherein the solubilized peptidic hydrolyzate comprises at least between 2 and 3 g/l of peptidic nature compounds.

### Claim 4 (depends on 2)

The method of claim 2, wherein the solubilized hydrolyzate is used in a quantity representing from 0.01% to 1% of the total weight of the composition.

### Claim 5 (depends on 1)

The method of claim 1, wherein the applying step is performed daily.

### Claim 6 (depends on 2)

The method of claim 2, wherein the applying step is performed daily.

### Claim 7 (depends on 2)

The method of claim 2, wherein the peptidic hydrolyzate is solubilized in one or more physiologically acceptable solvents, such as water, glycerol, ethanol, propylene glycol, butylene glycol, dipropylene glycol, ethoxylated diethylene glycol or propoxylated diethylene glycol, cyclic polyols, or any mixture of these solvents.

### Claim 8 (depends on 2)

The method of claim 2, wherein the solubilized peptidic hydrolyzate comprises at least between 1.5 and 4 g/l of peptidic nature compounds.

### Claim 9 (depends on 2)

The method of claim 2, wherein the solubilized hydrolyzate is used in a quantity representing from 0.001% to 5% of the total weight of the composition.

### Claim 10 (depends on 2)

The method of claim 2, further comprising a soy peptidic hydrolyzate.

### Claim 11 (depends on 10)

The method of claim 10, wherein the non-fermented rice peptidic hydrolyzate and the soy peptidic hydrolyzate are present at concentrations of between 10 and 90%.

### Claim 12 (depends on 2)

The method of claim 2, wherein at least 85% of the peptidic nature compounds present in the hydrolyzate are peptides with a size of less than 6 kDa.

### Claim 13 (depends on 1)

The method of claim 1, wherein the peptidic hydrolyzate is solubilized in one or more physiologically acceptable solvents, such as water, glycerol, ethanol, propylene glycol, butylene glycol, dipropylene glycol, ethoxylated diethylene glycol or propoxylated diethylene glycol, cyclic polyols, or any mixture of these solvents.