Treatment of conditions related to cecal ligation shock
AssigneeThe Regents of the University of California
InventorsGeert W. Schmid-Schonbein, Frank A. DeLano
Life of this patent
Estimating the term…
Abstract
Techniques, methods and lavages are disclosed for prevention or treatment of shock, particularly cecal ligation or cecal inoculation shock, by administering a specific therapeutic agent, which is able to use smaller volumes of reagent to achieve partial to complete inhibition, than other previously described techniques. The agent includes a combination of enzyme inhibitor, cytotoxic lipid binding protein, and antibiotic.
Claims19
A method for treatment of cecal ligation shock, the method comprising:
- administering into the peritoneal space of an individual at least a first therapeutic dose and into the lumen of the intestine at least a second therapeutic dose of a combination of a pancreatic digestive enzyme inhibitor, a cytotoxic lipid binding protein, and an antibiotic.
A method for treatment of multi-organ failure, the method comprising:
- administering into the peritoneal space of an individual at least a first therapeutic dose and into the lumen of the intestine at least a second therapeutic dose of a combination of a pancreatic digestive enzyme inhibitor, a cytotoxic lipid binding protein, and an antibiotic.
A method for reducing the incidence of mortality in cecal ligation shock, the method comprising:
- administering into the peritoneal space of an individual at least a first therapeutic dose and into the lumen of the intestine at least a second therapeutic dose of a combination of a pancreatic digestive enzyme inhibitor, a cytotoxic lipid binding protein, and an antibiotic.
A method for treatment of cecal ligation shock, the method comprising:
- administering into the peritoneal space of an individual of at least a first therapeutic dose and through an intravascular (iv) route at least a second therapeutic dose of a combination of a pancreatic digestive enzyme inhibitor, a cytotoxic lipid binding protein, and an antibiotic.
Dependencies are inferred from the claim text.