# US 8,541,364 B2 · Use of a octreotide as a therapeutic agent

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- Number: US 8,541,364 B2
- Document ID: US8541364B2
- Status: Granted
- Kind: B2
- Application number: 12/677,293
- Filed: 2008-09-09
- Published: 2011-03-17
- Granted: 2013-09-24
- Earliest claimed: 2007-09-11
- Assignees: mondoBIOTECH Laboratories AG
- Applicants: Dorian Bevec; Fabio Cavalli; Vera Cavalli; Gerald Bacher
- Inventors: Dorian Bevec; Fabio Cavalli; Vera Cavalli; Gerald Bacher
- Web page: https://patentgrep.com/patent/US8541364B2

## CPC

- A61K 38/043: {Kallidins; Bradykinins; Related peptides}
- A61K 38/12: Cyclic peptides {, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C (A61K38/043 - A61K38/046 take precedence)}
- A61K 38/34: Melanocyte stimulating hormone [MSH], e.g. alpha- or beta-melanotropin
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## Abstract

The present invention is directed to the use of the peptide compound D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-L-threoninol as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-L-threoninol optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.

## Claims

### Claim 1

A method of treatment of Mycobacterium tuberculosis infection, the method comprising,
administering to a patient in need thereof, a therapeutically effective amount of a pharmaceutical composition comprising a peptide consisting of the sequence D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-L-threoninol (SEQ ID NO:1) or salts or hydrates thereof, wherein administration of the pharmaceutical composition treats said diseases.

### Claim 2 (depends on 1)

The method of claim 1, wherein the peptide is administered by intravenous administration, oral administration, or administration by inhalation.

### Claim 3 (depends on 1)

The method of claim 1, wherein the peptide is administered as a lyophilized formulation or as a buffered liquid formulation.