# US 8,541,361 B2 · Composition > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,541,361 B2 - Document ID: US8541361B2 - Status: Granted - Kind: B2 - Application number: 13/264,059 - Filed: 2010-04-23 - Published: 2012-05-24 - Granted: 2013-09-24 - Earliest claimed: 2009-04-22 - Assignees: Dsm IP Assets B.V. - Applicants: Marc Heidl; Roman Wille; Hugo Ziegler - Inventors: Marc Heidl; Roman Wille; Hugo Ziegler - Web page: https://patentgrep.com/patent/US8541361B2 ## CPC - C07K 5/0815: {with the first amino acid being basic} - A61K 8/19: containing inorganic ingredients - A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof - A61P 17/00: Drugs for dermatological disorders - A61Q 19/00: Preparations for care of the skin - C07K 5/1019: {with the first amino acid being basic} - A61Q 19/06: for countering cellulitis - C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract The present invention relates to compositions comprising a peptide with 2-12 amino acids substituted with a lipophilic moiety and a water soluble salt of an alkali, earth alkaline metal or transition metal. Furthermore, the invention relates to a container comprising such compositions. Additionally, the invention relates to the use of a water soluble salt of an alkali, earth alkaline metal or transition metal for reducing the adhesion of a peptide with 2-12 amino acids substituted with a lipophilic moiety to a surface. ## Claims ### Claim 1 A method to reduce the adhesion of a peptide with 3-5 amino acids substituted with a saturated or unsaturated linear or branched chain hydrocarbon groups containing 8 to 20 carbon atoms, wherein said hydrocarbon group is connected thereto via an ester, amide, N-alkyl, N-alkenyl, sulfonyl, urethane or urea linkage to a surface, said method comprising combining said peptide with a water soluble salt of Mg, Ca, Zn and/ or Li. ### Claim 2 (depends on 1) The method of claim 1 wherein the peptide and water soluble salt are combined in an amount of 0.001-12.5 wt.-% peptide, and 0.00001-2 wt.-% water soluble salt, in a composition additionally comprising 10-95 wt.-%, of at least one water-soluble polyol containing 2 to 10 carbon atoms and 2 to 7 hydroxyl groups selected from the group consisting of ethylene glycol, 1,2-propylene glycol, 1,4-butylene glycol, glycerine, erythrit (meso-1,2,3,4-Butantetrol), sorbit, mannit, methylglucoside, diglycerine, triglycerine and pentaerythrit, and 10-90 wt.-%, of water wherein the total amount of ingredients of the composition sums up to 100 wt.%. ### Claim 3 (depends on 1) The method of claim 1 wherein the peptide and water soluble salt are combined in an amount of 0.01-2 wt.-% peptide, and 0.01-0.5 wt.-% water soluble salt, in a composition additionally comprising 40-80 wt.-% of at least one water-soluble polyol containing 2 to 10 carbon atoms and 2 to 7 hydroxyl groups selected from the group consisting of ethylene glycol, 1,2-propylene glycol, 1,4-butylene glycol, glycerine, erythrit (meso-1,2,3,4-Butantetrol), sorbit, mannit, methylglucoside, diglycerine, triglycerine and/ or pentaerythrit, and 20-50 wt.-% of water, wherein the total amount of ingredients of the composition sums up to 100 wt.-%. ### Claim 4 (depends on 1) The method of claim 1 wherein the peptide and water soluble salt are combined in an amount of 0.1-0.5 wt.-% peptide, and 0.02-0.01 wt.-% water soluble salt, in a composition additionally comprising 50-70 wt.-% of at least one water-soluble polyol containing 2 to 10 carbon atoms and 2 to 7 hydroxyl groups selected from the group consisting of ethylene glycol, 1,2-propylene glycol, 1,4-butylene glycol, glycerine, erythrit (meso-1,2,3,4-Butantetrol), sorbit, mannit, methylglucoside, diglycerine, triglycerine and/ or pentaerythrit, and 25-35 wt.-% of water, wherein the total amount of ingredients of the composition sums up to 100 wt.-%. ### Claim 5 (depends on 2) The method of claim 2, wherein the composition further comprising a cosmetically acceptable thickener and/ or a cosmetically acceptable tenside. ### Claim 6 (depends on 3) The method of claim 3, wherein the composition further comprising a cosmetically acceptable thickener and/ or a cosmetically acceptable tenside. ### Claim 7 (depends on 4) The method of claim 4, wherein the composition further comprising a cosmetically acceptable thickener and/ or a cosmetically acceptable tenside. ### Claim 8 (depends on 1) The method of claim 1, wherein the peptide is selected from Palm-Lys-Val-Lys-OH, Palm-Lys-Val-Dab-OH, Palm-Lys-Val-Dab-Thr-OH and/ or C14H29—NH—CO-Dab-Val-Dab-OH. ### Claim 9 (depends on 2) The method of claim 2, wherein the peptide is selected from Palm-Lys-Val-Lys-OH, Palm-Lys-Val-Dab-OH, Palm-Lys-Val-Dab-Thr-OH and/ or C14H29—NH—CO-Dab-Val-Dab-OH. ### Claim 10 (depends on 3) The method of claim 3, wherein the peptide is selected from Palm-Lys-Val-Lys-OH, Palm-Lys-Val-Dab-OH, Palm-Lys-Val-Dab-Thr-OH and/ or C14H29—NH—CO-Dab-Val-Dab-OH. ### Claim 11 (depends on 4) The method of claim 4, wherein the peptide is selected from Palm-Lys-Val-Lys-OH, Palm-Lys-Val-Dab-OH, Palm-Lys-Val-Dab-Thr-OH and/ or C14H29—NH—CO-Dab-Val-Dab-OH. ### Claim 12 (depends on 1) The method according to claim 1 wherein the water soluble salt is MgCl2. ### Claim 13 (depends on 2) The method according to claim 2 wherein the water soluble salt is MgCl2. ### Claim 14 (depends on 3) The method according to claim 3 wherein the water soluble salt is MgCl2. ### Claim 15 (depends on 4) The method according to claim 4 wherein the water soluble salt is MgCl2. ### Claim 16 (depends on 2) The method according to claim 2 wherein the at least one water-soluble polyol containing 2 to 10 carbon atoms and 2 to 7 hydroxyl groups is selected from glycerine, 1,2-propylene glycol and/ or 1,4-butylene glycol. ### Claim 17 (depends on 3) The method according to claim 3 wherein the at least one water-soluble polyol containing 2 to 10 carbon atoms and 2 to 7 hydroxyl groups is selected from glycerine, 1,2-propylene glycol and/ or 1,4-butylene glycol. ### Claim 18 (depends on 4) The method according to claim 4 wherein the at least one water-soluble polyol containing 2 to 10 carbon atoms and 2 to 7 hydroxyl groups is selected from glycerine, 1,2-propylene glycol and/ or 1,4-butylene glycol. ### Claim 19 (depends on 1) The method according to claim 1 wherein the surface is a container surface. ### Claim 20 (depends on 2) The method according to claim 2 wherein the surface is a container surface. ### Claim 21 (depends on 3) The method according to claim 3 wherein the surface is a container surface. ### Claim 22 (depends on 4) The method according to claim 4 wherein the surface is a container surface. ### Claim 23 (depends on 2) The method of claim 2, wherein the composition is a topical preparation comprising a cosmetically acceptable carrier. ### Claim 24 (depends on 3) The method of claim 3, wherein the composition is a topical preparation comprising a cosmetically acceptable carrier. ### Claim 25 (depends on 4) The method of claim 4, wherein the composition is a topical preparation comprising a cosmetically acceptable carrier. ### Claim 26 (depends on 2) The method of claim 2 wherein the peptide is combined in an amount of 0.01-2 wt.-%. ### Claim 27 (depends on 2) The method of claim 2 wherein the peptide is combined in an amount of 0.1-0.5 wt.%.