# US 8,541,360 B2 · Parenteral formulations comprising sugar-based esters and ethers

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- Number: US 8,541,360 B2
- Document ID: US8541360B2
- Status: Granted
- Kind: B2
- Application number: 12/619,785
- Filed: 2009-11-17
- Published: 2010-05-20
- Granted: 2013-09-24
- Earliest claimed: 2008-11-19
- Assignees: Ben Venue Laboratories, Inc.
- Applicants: Douglas L. Brown
- Inventors: Douglas L. Brown
- Web page: https://patentgrep.com/patent/US8541360B2

## CPC

- A61K 31/05: Phenols {(cannabinoids A61K31/658)}
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 9/19: lyophilised {, i.e. freeze-dried, solutions or dispersions (lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00)}
- A61K 31/337: having four-membered rings, e.g. taxol
- A61K 31/7048: having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin {, digitoxin or digoxin}
- A61P 35/00: Antineoplastic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to formulations for the parenteral administration of therapeutic agents, which contain sugar-based esters and ethers of fatty acids and fatty alcohols as surfactants. The formulations are advantageous for therapeutic agents which are insoluble or poorly soluble in water, and for reducing toxicity associated with common surfactants used in pharmaceutical formulations.

## Claims

### Claim 1

A pharmaceutical solution for injection or infusion administration comprising a therapeutic agent selected from the group consisting of taxanes, antineoplastics, anaesthetics, steroids and antibiotics and sucrose cocoate.

### Claim 2 (depends on 1)

The composition of claim 1, wherein the therapeutic agent is poorly soluble in water.

### Claim 3 (depends on 1)

The composition of claim 1, wherein the composition further comprises a bulking agent.

### Claim 4 (depends on 1)

The composition of claim 1, wherein the composition further comprises a tonicity agent.

### Claim 5 (depends on 1)

The composition of claim 1, wherein the composition further comprises a preservative.

### Claim 6 (depends on 1)

The composition of claim 1, the therapeutic agent being a taxane.

### Claim 7 (depends on 6)

The composition of claim 6, the therapeutic agent being docetaxel.

### Claim 8 (depends on 1)

The composition of claim 1, the therapeutic agent being an anaesthetic.

### Claim 9 (depends on 1)

The composition of claim 1, the therapeutic agent being a steroid.

### Claim 10 (depends on 1)

The composition of claim 1, the therapeutic agent being an antibiotic.