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US 8,541,231 B2Granted
Elimination of N-glycolylneuraminic acid from animal products for human use
AssigneeThe Regents of the University of California
InventorsAjit Varki, Anna Maria Hedlund, Dzung Nguyen
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Abstract
The application is in the field of transgenic (non-human) organisms, sialic acid chemistry, metabolism and antigenicity. More particularly, the invention is related to a method to produce Neu5Gc-free animals and products therefrom comprising disrupting the CMAH gene and thereby reducing or eliminating Neu5Gc from biological material of non-humans.
Claims2
A cell line isolated from a viable and fertile transgenic mouse that
- a) comprises a genome having a homozygous mutation of the cytidine-5′-monophosphate N-acetyl neuraminic acid hydrolase (CMAH) gene,
- b) lacks expression of enzymatically active CMAH protein encoded by said CMAH gene, and
- c) lacks N-glycolylneuraminic acid (Neu5Gc) in one or more body fluid or tissue.
Dependencies are inferred from the claim text.