Process for the production of fine chemicals

A process for the production of a fine chemical, comprising increasing or generating in an organism or a part thereof the expression of at least one nucleic acid molecule comprising a nucleic acid molecule selected from the group consisting of:

• a) a nucleic acid molecule encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:
• 42011;
• b) a nucleic acid molecule comprising the nucleic acid molecule of SEQ ID NO:
• 42010;
• c) a nucleic acid molecule which encodes a polypeptide comprising a polypeptide which has at least 90% sequence identity with the amino acid sequence of SEQ ID NO:
• 42011 and conferring an increase in the amount of the fine chemical in the organism or part thereof;
• d) a fragment of the nucleic acid molecule of (a) having at least 500 nucleotides which confers an increase in the amount of a fine chemical in the organism or part thereof;
• and
• e) a nucleic acid molecule encoding a polypeptide which is isolated with the aid of monoclonal antibodies against a polypeptide encoded by one of the nucleic acid molecules of (a) or (b) and conferring an increase in the amount of the fine chemical in an organism or a part thereof;
• and
• f) a nucleic acid molecule encoding the polypeptide of SEQ ID NO:
• 42011 or an enzymatically active fragment thereof and conferring an increase in the amount of the fine chemical in an organism or a part thereof;
• wherein the organism or part thereof is selected from the group consisting of a microorganism, a plant cell, a plant, a plant tissue, and one or more parts thereof;
• and
• wherein the fine chemical is selected from the group consisting of threonine, tryptophane, glutamate, ferulic acid, and mixtures thereof.

A process for the control of the production of a fine chemical comprising

• (a) increasing or generating the activity of the protein comprising the polypeptide sequence of SEQ ID NO:
• 42011 or an enzymatically active fragment thereof, in a non-human organism or in one or more parts thereof;
• and
• (b) growing the organism or part thereof under conditions which permit the production of the fine chemical in said organism or part thereof;
• wherein the organism or part thereof is selected from the group consisting of a microorganism, a plant cell, a plant, a plant tissue, and one or more parts thereof;
• and
• wherein the fine chemical is selected from the group consisting of threonine, tryptophane, glutamate, ferulic acid, and mixtures thereof.

A process for the control of the production of fine chemicals comprising

• (a) increasing or generating the activity of the protein comprising the polypeptide sequence of SEQ ID NO:
• 42011 or an enzymatically active fragment thereof, in a non-human organism or in one or more parts thereof;
• and
• (b) growing the organism under conditions which permit the production of fine chemicals in defined ratios in said organism resulting in a defined metabolic profile;
• wherein the organism or part thereof is selected from the group consisting of a microorganism, a plant cell, a plant, a plant tissue, and one or more parts thereof;
• and
• wherein the fine chemical is selected from the group consisting of threonine, tryptophane, glutamate, ferulic acid, and mixtures thereof.

A process for the control of the production of fine chemicals comprising expressing in an organism or a part thereof at least one nucleic acid molecule comprising a nucleic acid molecule selected from the group consisting of:

• a) a nucleic acid molecule encoding a polypeptide comprising the sequence of SEQ ID NO:
• 42011;
• b) a nucleic acid molecule comprising a nucleic acid molecule having the sequence of SEQ ID NO:
• 42010,
• c) a nucleic acid molecule encoding a polypeptide comprising an amino acid sequence which has at least 90% sequence identity with the amino acid sequence of SEQ ID NO:
• 42011 and conferring an increase in the amount of the fine chemical in an organism or a part thereof;
• d) a fragment of the nucleic acid molecule of (a) having at least 500 nucleotides which confers an increase in the amount of a fine chemical in the organism or part thereof;
• and
• e) a nucleic acid molecule encoding the polypeptide of SEQ ID NO:
• 42011 or an enzymatically active fragment thereof and conferring an increase or decrease in the amount of the respective fine chemical in an organism or a part thereof;
• and
• f) a nucleic acid molecule encoding a polypeptide which is isolated with the aid of monoclonal antibodies against a polypeptide encoded by one of the nucleic acid molecules of (a) or (b) and conferring an increase in the amount of the fine chemical in an organism or a part thereof;
• wherein the organism or part thereof is selected from the group consisting of a microorganism, a plant cell, a plant, a plant tissue, and one or more parts thereof;
• and
• wherein the fine chemical is selected from the group consisting of threonine, tryptophane, glutamate, ferulic acid, and mixtures thereof.

A process for the production of a composition of fine chemicals comprising

• (a) increasing or generating the activity of the protein comprising the polypeptide sequence of SEQ ID NO:
• 42011 or an enzymatically active fragment thereof, in a non-human organism or in one or more parts thereof;
• and
• (b) growing the organism or part thereof under conditions which permit the production of a composition of fine chemicals in said organism or part thereof wherein the metabolite content is increased compared to a corresponding wild type cell, microorganism, plant cell, plant, plant tissue or one or more parts thereof;
• wherein said composition is a biological composition;
• wherein the organism or part thereof is selected from the group consisting of a microorganism, a plant cell, a plant, a plant tissue, and one or more parts thereof;
• and
• wherein the fine chemical is selected from the group consisting of threonine, tryptophane, glutamate, ferulic acid, and mixtures thereof.