# US 8,541,202 B2 · Method for inducing cell lysis with immunogenic portions of NY-ESO-1 protein

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- Number: US 8,541,202 B2
- Document ID: US8541202B2
- Status: Granted
- Kind: B2
- Application number: 13/404,633
- Filed: 2012-02-24
- Published: 2012-09-13
- Granted: 2013-09-24
- Earliest claimed: 1996-10-03
- Assignees: Ludwig Institute for Cancer Research
- Applicants: Alexander Knuth; Elke Jäger; Yao-tseng Chen; Matthew Scanlan; Ali Gure; Gerd Ritter; Lloyd J. Old; Jan W. Drijfhout
- Inventors: Alexander Knuth; Elke Jäger; Yao-tseng Chen; Matthew Scanlan; Ali Gure; Gerd Ritter; Lloyd J. Old; Jan W. Drijfhout
- Web page: https://patentgrep.com/patent/US8541202B2

## CPC

- C07K 14/4748: {Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE}
- A61P 35/00: Antineoplastic agents
- A61P 37/04: Immunostimulants
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- Y10S 435/81: Packaged device or kit
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

## Abstract

The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.

## Claims

### Claim 1

A method for recombinantly producing an NY-ESO-1 protein comprising transforming or transfecting a cell with a nucleic acid molecule which consists of a nucleotide sequence which encodes a part of the protein encoded by the nucleotide sequence set forth in SEQ ID NO: 1, operably linked to a promoter, in an amount sufficient to express said protein, culturing said cell to recombinantly produce said NY-ESO-1 protein, and isolating said NY-ESO-1 protein.

### Claim 2 (depends on 1)

The method of claim 1, wherein said nucleotide sequence set forth in SEQ ID NO: 1 encodes at least amino acids 10-121 of NY-ESO-1 protein.

### Claim 3 (depends on 2)

The method of claim 2, wherein said nucleotide sequence set forth in SEQ ID NO: 1 encodes no more than amino acids 10-180 of said NY-ESO-1 protein.

### Claim 4 (depends on 1)

The method of claim 1, wherein said nucleotide sequence comprises at least nucleotides 54-593 of SEQ ID NO: 1.

### Claim 5 (depends on 1)

The method of claim 1, wherein said cell is a prokaryotic cell.

### Claim 6 (depends on 2)

The method of claim 2, wherein said cell is a eukaryotic cell.