# US 8,541,201 B2 · Thrombopoietic compounds

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- Number: US 8,541,201 B2
- Document ID: US8541201B2
- Status: Granted
- Kind: B2
- Application number: 13/186,443
- Filed: 2011-07-19
- Published: 2011-11-10
- Granted: 2013-09-24
- Earliest claimed: 2006-06-19
- Assignees: Amgen Inc.
- Applicants: Hosung Min; Kenneth W. Walker; Colin V. Gegg; Francesco Galimi; Jeonghoon Sun; Mei-Mei Tsai
- Inventors: Hosung Min; Kenneth W. Walker; Colin V. Gegg; Francesco Galimi; Jeonghoon Sun; Mei-Mei Tsai
- Web page: https://patentgrep.com/patent/US8541201B2

## CPC

- C07K 14/524: {Thrombopoietin, i.e. C-MPL ligand}
- A61K 38/17: from animals; from humans {(enzyme inhibitors A61K38/005)}
- A61P 7/02: Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C07K 7/06: having 5 to 11 amino acids
- C07K 7/08: having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68)
- C07K 14/001: {by chemical synthesis}
- C07K 2319/30: Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention relates to the field of compounds, especially peptides or polypeptides, that have thrombopoietic activity. The peptides and polypeptides of the invention may be used to increase platelets or platelet precursors (e.g., megakaryocytes) in a mammal.

## Claims

### Claim 1

An isolated polynucleotide that encodes a compound that binds to an mpl receptor, wherein said compound is selected from the group consisting of SEQ ID NOS: 353-422.

### Claim 2 (depends on 1)

A vector that comprises the polynucleotide of claim 1.

### Claim 3 (depends on 2)

An isolated host cell that comprises the vector of claim 2.

### Claim 4 (depends on 3)

A method of producing a compound that binds to an mpl receptor which comprises growing the host cell of claim 3 in a suitable nutrient medium and isolating said compound from said cell or nutrient medium.