# US 8,541,173 B2 · Endometriosis-related markers and uses thereof

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- Number: US 8,541,173 B2
- Document ID: US8541173B2
- Status: Granted
- Kind: B2
- Application number: 13/403,903
- Filed: 2012-02-23
- Published: 2012-08-16
- Granted: 2013-09-24
- Earliest claimed: 2000-02-25
- Assignees: Siemens Healthcare Diagnostics Inc.
- Applicants: Soheyl Baban; Monique Bernard; Elana Cherry; Diane Gosselin; Patrice Hugo; Brigitte Malette; Pierre Miron; Charles Privé; Kamran Shazand
- Inventors: Soheyl Baban; Monique Bernard; Elana Cherry; Diane Gosselin; Patrice Hugo; Brigitte Malette; Pierre Miron; Charles Privé; Kamran Shazand
- Web page: https://patentgrep.com/patent/US8541173B2

## CPC

- C12Q 1/6883: for diseases caused by alterations of genetic material
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- C12Q 2600/158: Expression markers
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to markers of endometriosis which are differentially expressed in the endometrial cells of females with endometriosis compared to endometriosis-free females. The invention also relates to methods for determining likelihood of endometriosis in female subjects, to methods for grading endometriosis in females suffering from endometriosis and to methods for treating this disease. The invention is also concerned with polynucleotides, probes, primers and kits useful for reducing into practice the above-mentioned methods which are more rapid, non invasive, much less complicated and much less costly than laparoscopy.

## Claims

### Claim 1

A method for determining the likelihood of endometriosis in a female subject, comprising the steps of: obtaining a sample of endometrial cells from said female subject; assaying said endometrial cells sample for the expression level of at least one endometriosis-related marker, said marker being a protein encoded by the gene of CAP43 or fragments of said protein which are immunoreactive to CAP43 antibodies, whereby the expression level of said at least one endometriosis-related marker being indicative of the likelihood of endometriosis in said female subject.

### Claim 2 (depends on 1)

The method of claim 1 wherein said endometriosis-related marker is a protein expressed by the polynucleotide having the sequence SEQ ID NO: 5 or fragments of said protein which are immunoreactive to CAP43 antibodies.

### Claim 3

A method for determining the likelihood of endometriosis in a female subject, comprising the steps of: obtaining a sample of endometrial cells from said female subject; assaying said endometrial cells sample for the expression level of at least one endometriosis-related marker, said marker being the protein expressed by the polynucleotide having the sequence of SEQ ID NO: 5, the expression level of said at least one endometriosis-related marker being indicative of the likelihood of endometriosis in said female subject.