# US 8,541,029 B2 · Article and method for focused delivery of therapeutic and/or diagnostic materials > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,541,029 B2 - Document ID: US8541029B2 - Status: Granted - Kind: B2 - Application number: 13/337,570 - Filed: 2011-12-27 - Published: 2012-04-19 - Granted: 2013-09-24 - Earliest claimed: 2006-10-17 - Assignees: Armark Authentication Technologies, LLC - Applicants: Peter D. Gabriele; Michael S. Flemmens; Jeffrey H. Robertson; Andrew Hogan - Inventors: Peter D. Gabriele; Michael S. Flemmens; Jeffrey H. Robertson; Andrew Hogan - Web page: https://patentgrep.com/patent/US8541029B2 ## CPC - A61K 9/0009: {involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis} - A61K 9/70: Web, sheet or filament bases {; Films; Fibres of the matrix type containing drug (hollow drug-filled fibres A61K9/0092)} - A61K 31/167: having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol - A61P 25/00: Drugs for disorders of the nervous system - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract A microfiber extrudate and delivery process includes a bio-compatible polymer matrix forming a body of the microfiber extrudate, an exogenously excitable material arranged within the body, and an active load arranged within the body. ## Claims ### Claim 1 A microfiber extrudate delivery process comprising: identifying a region in an animal; medically administering a microfiber extrudate to the region in the animal, the microfiber extrudate comprising: a bio-compatible polymer matrix forming a body of the microfiber extrudate; a material arranged within the microfiber extrudate body; and an active load arranged as a discrete domain within the microfiber extrudate body; and thereafter applying exogenous stimulus to the region in the animal from outside of the animal, thereby releasing the active load from the microfiber extrudate body into the region in the animal; wherein the step of applying exogenous stimulus to the material to release the active load comprises applying an exogenous stimulus selected from the group consisting of radiofrequency excitation, microwave excitation, terahertz excitation, mid infrared excitation, near infrared excitation, visible excitation, ultraviolet excitation, x-irradiation excitation, magnetic excitation, electron beam irradiation excitation, and combinations thereof; wherein the material is a superparamagnetic iron oxide nano-particle. ### Claim 2 (depends on 1) The delivery process of claim 1, wherein the step of medically administering comprises medically administering a microfiber extrudate having a diameter of less than about 110 micrometers. ### Claim 3 (depends on 1) The delivery process of claim 1, wherein the medically administered microfiber extrudate comprises the material arranged in at least one discrete domain. ### Claim 4 (depends on 1) The delivery process of claim 1, wherein the medically administered microfiber extrudate has a size and geometry substantially similar to a red blood cell or white blood cell. ### Claim 5 (depends on 1) The delivery process of claim 1, wherein the medically administered microfiber extrudate is disc-shaped. ### Claim 6 (depends on 1) The delivery process of claim 1, wherein the medically administered microfiber extrudate has a transverse thickness of less than about 12 micrometers. ### Claim 7 (depends on 1) The delivery process of claim 1, wherein the active load of the medically administered microfiber extrudate comprises an active pharmaceutical ingredient. ### Claim 8 (depends on 7) The delivery process of claim 7, wherein the active pharmaceutical ingredient includes acetaminophen. ### Claim 9 (depends on 1) The delivery process of claim 1, wherein the active load of the medically administered microfiber extrudate comprises an antibody. ### Claim 10 (depends on 1) The delivery process of claim 1, wherein the active load of the medically administered microfiber extrudate comprises an anti-VEGH. ### Claim 11 (depends on 1) The delivery process of claim 1, wherein the material of the medically administered microfiber extrudate is a radiosensitive chemotherapeutic agent. ### Claim 12 (depends on 1) The delivery process of claim 1, wherein the active load of the medically administered microfiber extrudate is a non-radiosensitive chemotherapeutic agent. ### Claim 13 (depends on 1) The delivery process of claim 1, wherein the bio-compatible polymer matrix of the medically administered microfiber extrudate comprises a polyglycolide copolymer. ### Claim 14 A microfiber extrudate delivery process comprising: identifying a region in a human; medically administering a microfiber extrudate to the region in the human, the microfiber extrudate comprising: a polyglycolide copolymer base bio-compatible polymer matrix forming a body of the microfiber extrudate; a paramagnetic material arranged within the microfiber extrudate body; and an active pharmaceutical ingredient arranged as a discrete domain within the microfiber extrudate body; and thereafter applying radio-frequency stimulation to the region in the human from outside of the human to stimulate the paramagnetic material and release the active load from the microfiber extrudate body into the region in the human; wherein the microfiber extrudate is constructed from a micro-extrusion fiber spinning process; wherein the step of applying exogenous stimulus to the material to release the active load comprises applying an exogenous stimulus selected from the group consisting of radiofrequency excitation, microwave excitation, terahertz excitation, mid infrared excitation, near infrared excitation, visible excitation, ultraviolet excitation, x-irradiation excitation, magnetic excitation, electron beam irradiation excitation, and combinations thereof; wherein the material is a superparamagnetic iron oxide nano-particle. ### Claim 15 (depends on 14) The microfiber extrudate delivery process of claim 14, wherein the medically administered microfiber extrudate further comprises an anti-body.