# US 8,541,027 B2 · Fixation devices for tissue repair

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- Number: US 8,541,027 B2
- Document ID: US8541027B2
- Status: Granted
- Kind: B2
- Application number: 10/479,746
- Filed: 2002-05-31
- Published: 2004-12-30
- Granted: 2013-09-24
- Earliest claimed: 2001-06-06
- Assignees: Smith & Nephew, Inc.
- Applicants: Emma Jayne Wright; James William Huckle; Saad Aboul Majeed Ali
- Inventors: Emma Jayne Wright; James William Huckle; Saad Aboul Majeed Ali
- Web page: https://patentgrep.com/patent/US8541027B2

## CPC

- A61L 31/148: {Materials at least partially resorbable by the body}
- A61L 31/048: {obtained by reactions only involving carbon-to-carbon unsaturated bonds (A61L31/041 takes precedence)}
- A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)}
- A61L 33/0011: {Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate}
- A61L 2300/412: Tissue-regenerating or healing or proliferative agents
- A61L 2300/414: Growth factors
- A61L 2300/606: Coatings
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)

## Abstract

Fixation devices for tissue repair, for example sutures, surgical arrows, staples, darts, bolts, screws, buttons, anchors, nails, rivets or barbed devices comprise at least one of angiogenic material; angiogenic precursor material which is capable of breaking down in vivo to form angiogenic material; and tissue-engineered material, which tissue-engineered material is capable of producing angiogenic material. In a preferred form the material is incorporated into a polymer matrix having predetermined hydrophobicity to allow controlled release of angiogenic materials such as butyric or hydroxybutyric acid or salts thereof. Polymer matrix compositions comprising angiogenic materials and methods for tissue repair are also provided.

## Claims

### Claim 1

A fixation device for tissue repair comprising a water soluble or water miscible angiogenic material or precursor thereof in admixture with a non-absorbable hydrophobic polymer, wherein the angiogenic material is sodium butyrate.

### Claim 2 (depends on 1)

The fixation device according to claim 1 wherein the polymer includes up to about 15% by weight of the angiogenic material.

### Claim 3 (depends on 1)

The fixation device according to claim 1 wherein the fixation device comprises a suture, a surgical arrow, a staple, a dart, a bolt, a screw, a button, an anchor, a nail or rivet, or a barbed surgical device.

### Claim 4

A fixation device for tissue repair consisting of a water-soluble or water miscible angiogenic material or precursor thereof in admixture with a non-absorbable hydrophobic polymer, wherein the angiogenic material is sodium butyrate.