# US 8,541,022 B2 · Method of treating burns using avermectin compound

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- Number: US 8,541,022 B2
- Document ID: US8541022B2
- Status: Granted
- Kind: B2
- Application number: 12/156,496
- Filed: 2008-06-02
- Published: 2009-12-03
- Granted: 2013-09-24
- Earliest claimed: 2008-06-02
- Assignees: Galderma S.A.
- Applicants: L. Dean Parks; Jeffrey D. Parks
- Inventors: L. Dean Parks; Jeffrey D. Parks
- Web page: https://patentgrep.com/patent/US8541022B2

## CPC

- A61K 31/351: not condensed with another ring
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 31/7048: having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin {, digitoxin or digoxin}
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A method of treating a superficial or partial thickness burn caused by heat, or by UV or laser radiation is disclosed. The method includes topically applying a topical composition containing an avermectin compound to an affected area immediately after a burn occurs. The method further includes cooling the affected area with ice or water prior to application of the topical composition. Additionally, the method includes topically applying a second topical composition containing fluocinonide and salicylic acid on the affected area to further enhance anti-inflammatory effect of the avermectin compound on the damaged skin.

## Claims

### Claim 1

A method for reducing pain and blistering caused by a superficial or partial thickness burn, comprising topically applying a topical composition comprising an effective amount of an avermectin compound to an affected area of the skin of an individual immediately after a burn caused by heat, or by UV or laser radiation occurs, thereby reducing said pain and blistering.

### Claim 2 (depends on 1)

The method of claim 1, wherein said topically applying said topical composition is within 5 seconds to 45 minutes after said burn occurs.

### Claim 3 (depends on 2)

The method of claim 2, wherein said topically applying said topical composition is within 5 seconds to 15 minutes after said burn occurs.

### Claim 4 (depends on 2)

The method of claim 2 further comprising cooling said affected area with ice or water prior to said applying said topical composition.

### Claim 5 (depends on 2)

The method of claim 2 further comprising topically applying said topical composition to said affected area of said individual subsequently one or more times.

### Claim 6 (depends on 2)

The method of claim 2 further comprising topically applying a second topical composition comprising fluocinonide and salicylic acid on said affected area.

### Claim 7 (depends on 1)

The method of claim 1, wherein said topical composition comprises an effective amount of said avermectin compound and a pharmaceutically acceptable carrier.

### Claim 8 (depends on 7)

The method of claim 7, wherein said avermectin compound comprises avermectins, avermectin derivatives, ivermectin, or ivermectin derivatives.

### Claim 9 (depends on 8)

The method of claim 8, wherein said avermectin compound is ivermectin in a concentration greater than 0.01% (w/w) in said topical composition.

### Claim 10 (depends on 8)

The method of claim 8, wherein said ivermectin is in a concentration range from about 0.03% to about 5.0% (w/w).

### Claim 11 (depends on 7)

The method of claim 7, wherein said topical composition is in a form of emulsion, gel, lotion, cream, or spray.

### Claim 12 (depends on 7)

The method of claim 7, wherein said topical composition is integrated in a topical dressing, medicated tape, or dermal patch.