# US 8,541,020 B2 · Polymeric hydrogel

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- Number: US 8,541,020 B2
- Document ID: US8541020B2
- Status: Granted
- Kind: B2
- Application number: 10/485,829
- Filed: 2002-09-17
- Published: 2004-09-30
- Granted: 2013-09-24
- Earliest claimed: 2001-09-18
- Assignees: Seikisui Plastics Co., Ltd.
- Applicants: Shuichi Sasahara; Kazuhiro Yosikawa; Shinichi Wakamatsu; Takahiko Fujita
- Inventors: Shuichi Sasahara; Kazuhiro Yosikawa; Shinichi Wakamatsu; Takahiko Fujita
- Web page: https://patentgrep.com/patent/US8541020B2

## CPC

- C08L 71/02: Polyalkylene oxides
- A61K 9/0009: {involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis}
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/24: containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
- A61K 47/34: Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence)
- C08G 65/2654: {Aluminium or boron; Compounds thereof}
- C08G 65/34: from hydroxy compounds or their metallic derivatives {(C08G65/26 takes precedence)}
- C08L 101/14: the macromolecular compounds being water soluble or water swellable, e.g. aqueous gels
- C09J 133/24: Homopolymers or copolymers of amides or imides
- C08L 2666/02: Organic macromolecular compounds, natural resins, waxes or and bituminous materials
- C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C08G: MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C09J: ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES (preparation of glue or gelatine C09H)

## Abstract

The invention aims at providing a polymeric hydrogel which is highly resistant to water washing. The aim is attained by a polymeric hydrogel comprising a polymeric matrix formed by copolymerizing a nonionic polymerizable monomer with a crosslinking monomer, characterized in that the polymeric matrix contains a wetting agent and water, at least 50 wt % of the wetting agent is constituted of a polymer prepared by polymerizing a polyhydric alcohol monomer component containing a trihydric or more alcohol monomer, and the polymer is a water-soluble one which has an average molecular weight of 150 to 4000 and satisfies the relationship: {(number of ether groups in the polymer+number of hydroxyl groups in the polymer)/number of carbon atoms present in the polymer}≧1/3.

## Claims

### Claim 1

A polymeric hydrogel comprising a polymeric matrix formed by copolymerizing a nonionic polymerizable monomer with a crosslinking monomer, wherein the polymeric matrix contains a wetting agent and water, at least 50 wt % of the wetting agent is constituted of a polymer chosen from polyglycerin having 8 to 12 hydroxyl groups, and the polymer is water-soluble and has an average molecular weight of 150 to 4000 and satisfies the relationship: {(number of ether groups in the polymer+number of hydroxyl groups in the polymer)/number of carbon atoms present in the polymer}≧1/3, wherein the nonionic polymerizable monomer is selected from acrylamide, polyethyleneglycol methacrylate, N,N-dimethylacrylamide, and polypropyleneglycol acrylate, wherein the crosslinking monomer is selected from N,N-methylenebisacrylamide and polyethyleneglycol dimethacrylate.

### Claim 2 (depends on 1)

The polymeric hydrogel according to claim 1, wherein the polymeric hydrogel contains 5 to 50 wt % water.

### Claim 3 (depends on 1)

The polymeric hydrogel according to claim 1, wherein the polymeric hydrogel comprises up to 13% dissolved electrolyte.

### Claim 4 (depends on 1)

The polymeric hydrogel according to claim 1, wherein the polymeric hydrogel is used as a bioelectrode or medical adhesive.

### Claim 5 (depends on 1)

The polymeric hydrogel according to claim 1, wherein the polyglycerin comprises a polyglycerin having 8 hydroxyl groups.

### Claim 6 (depends on 1)

The polymeric hydrogel according to claim 1, wherein the polyglycerin comprises a polyglycerin having 12 hydroxyl groups.

### Claim 7 (depends on 1)

The polymeric hydrogel according to claim 1, wherein the polymer is water-soluble and has an average molecular weight of 500 to 750.