# US 8,541,019 B2 · Palatable ductile chewable veterinary composition

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- Number: US 8,541,019 B2
- Document ID: US8541019B2
- Status: Granted
- Kind: B2
- Application number: 13/285,724
- Filed: 2011-10-31
- Published: 2012-02-23
- Granted: 2013-09-24
- Earliest claimed: 2003-07-30
- Assignees: Novartis AG
- Applicants: Ute Isele
- Inventors: Ute Isele
- Web page: https://patentgrep.com/patent/US8541019B2

## CPC

- A61K 9/0056: {Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals}
- A23K 20/163: Sugars; Polysaccharides
- A23K 20/195: Antibiotics
- A23K 40/20: by moulding, e.g. making cakes or briquettes
- A23K 40/25: by extrusion
- A23K 50/42: Dry feed
- A61K 31/17: having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine (isoureas, isothioureas A61K31/155; sulfonylureas A61K31/64)
- A61K 31/365: Lactones
- A61K 31/4985: Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A61K 38/13: Cyclosporins
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/36: Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A61P 1/08: for nausea, cinetosis or vertigo; Antiemetics
- A61P 19/00: Drugs for skeletal disorders
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 25/02: for peripheral neuropathies
- A61P 25/14: for treating abnormal movements, e.g. chorea, dyskinesia
- A61P 25/22: Anxiolytics
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 31/04: Antibacterial agents
- A61P 31/12: Antivirals
- A61P 33/00: Antiparasitic agents
- A61P 33/02: Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P 33/10: Anthelmintics
- A61P 33/14: Ectoparasiticides, e.g. scabicides
- A61P 35/00: Antineoplastic agents
- A61P 35/04: specific for metastasis
- A61P 37/06: Immunosuppressants, e.g. drugs for graft rejection
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23K: FODDER
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention is directed to palatable ductile chewable veterinary composition for oral administration. The composition is capable of killing endo-parasites and ecto-parasites and/or can be used for treating prophylactic or curative animal diseases, and it is useful for the treatment of any warm-blooded non-human animal, including herd animals, like horses, cattle, sheep or poultry and preferably pets like dogs and cats. It consists basically of (A) an effective amount of one or more ingredients that are active against animal pests, pathogens or animal diseases; (B) meat flavoring; (C) partially gelatinized starch; (D) a softener; and (E) up to 9% water.

## Claims

### Claim 1

A highly palatable ductile chewable veterinary composition which is an extrudate, comprising (a) an effective amount of milbemycin oxime; (b) natural meat flavoring; (c) about 25 to about 70% (w/w) of partially gelatinized starch wherein said partially gelatinized starch comprises about 12 to about 17% (w/w) of gelatinized starch; (d) a softener; and (e) up to about 9% water.

### Claim 2 (depends on 1)

A chewable veterinary composition according to claim 1 comprising 20 to 30% (w/w) of natural meat flavoring.

### Claim 3 (depends on 2)

A chewable veterinary composition according to claim 2 wherein the natural meat flavoring comprises about 20 to about 55% (w/w) fat.

### Claim 4 (depends on 1)

A chewable veterinary composition according to claim 1 comprising about 10 to about 20% NM of a softener, based upon the weight of the partially gelatinized starch.

### Claim 5 (depends on 4)

A chewable veterinary composition according to claim 4 wherein the softener is selected from the group consisting of glycerol, polyethylene glycol and polypropylene glycol.

### Claim 6 (depends on 1)

A chewable veterinary composition according to claim 1 comprising about 4 to about 6% (w/w) of water.

### Claim 7 (depends on 1)

A chewable veterinary composition according to claim 1 further comprising about 1 to about 10% (w/w) of a sweetener.

### Claim 8 (depends on 1)

A chewable veterinary composition according to claim 1 further comprising 0 to about 3.5% (w/w) of an antioxidant.

### Claim 9 (depends on 1)

A chewable veterinary composition according to claim 1 further comprising 0 to about 5% (w/w) of a coloring agent.

### Claim 10 (depends on 1)

A chewable veterinary composition according to claim 1 further comprising 0 to about 4% (w/w) of sodium chloride.

### Claim 11 (depends on 1)

A chewable veterinary composition according to claim 1 further comprising an effective amount of praziquantel.

### Claim 12 (depends on 1)

A chewable veterinary composition according to claim 1 further comprising an effective amount each of lufenuron and praziquantel.

### Claim 13 (depends on 1)

A method of controlling nonhuman animal pests or nonhuman animal pathogens in an animal in need of said controlling, which comprises feeding an animal a palatable ductile chewable veterinary composition according to claim 1.

### Claim 14 (depends on 13)

The method of claim 13 wherein the amount of milbemycin oxime is adjusted to the bodyweight of the nonhuman animal that is in need of the treatment.

### Claim 15 (depends on 13)

The method of claim 13 wherein the composition comprises about 20 to about 30% (w/w) of a natural meat flavoring.

### Claim 16 (depends on 15)

The method of claim 15 wherein the natural meat flavoring comprises about 20 to about 55% (w/w) fat.

### Claim 17 (depends on 13)

The method of claim 13 wherein the composition comprises about 10 to about 20% (w/w) of a softener, based upon the weight of the partially gelatinized starch.

### Claim 18 (depends on 17)

The method of claim 17 wherein the softener is selected from the group consisting of glycerol, polyethylene glycol and polypropylene glycol.

### Claim 19 (depends on 13)

The method of claim 13 wherein the composition comprises about 3 to about 7% (w/w) of water.

### Claim 20 (depends on 13)

The method of claim 13 wherein the animal pests are external animal parasites or internal animal parasites or both.

### Claim 21 (depends on 13)

The method of claim 13 wherein the composition further comprises about 1 to about 10% (w/w) of a sweetener.

### Claim 22 (depends on 13)

The method of claim 13 wherein the composition further comprises 0 to about 3.5% (w/w) of an antioxidant.

### Claim 23 (depends on 13)

The method of claim 13 wherein the composition further comprises 0 to about 5% (w/w) of a coloring agent.

### Claim 24 (depends on 13)

The method of claim 13 wherein the composition further comprises 0 to about 4% (w/w) of sodium chloride.

### Claim 25 (depends on 13)

The method of claim 13 wherein the composition comprises an effective amount of praziquantel.

### Claim 26 (depends on 13)

The method of claim 13 wherein the composition further comprises comprising an effective amount each of lufenuron and praziquantel.