# US 8,541,010 B2 · Cosmetic composition comprising double-shell nano-structure > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,541,010 B2 - Document ID: US8541010B2 - Status: Granted - Kind: B2 - Application number: 13/023,804 - Filed: 2011-02-09 - Published: 2012-01-19 - Granted: 2013-09-24 - Earliest claimed: 2010-07-13 - Assignees: Woongjin Coway Co., Ltd. - Applicants: Sung-Bo Shim; Byoung-Young Jeon; Joo-Hyuck Lim; Jong-Keun Choi; Yong-Joon Joo; Jin-Hun Cho - Inventors: Sung-Bo Shim; Byoung-Young Jeon; Joo-Hyuck Lim; Jong-Keun Choi; Yong-Joon Joo; Jin-Hun Cho - Web page: https://patentgrep.com/patent/US8541010B2 ## CPC - A61K 8/90: Block copolymers (A61K8/89 takes precedence) - A61K 8/0241: {Containing particulates characterized by their shape and/or structure (see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes)} - A61K 8/11: Encapsulated compositions - A61K 8/553: {Phospholipids, e.g. lecithin} - A61K 8/676: {Ascorbic acid, i.e. vitamin C} - A61K 8/97: from algae, fungi, lichens or plants; from derivatives thereof - A61K 8/9789: Magnoliopsida [dicotyledons] - A61Q 19/00: Preparations for care of the skin - A61K 2800/412: Microsized, i.e. having sizes between 0.1 and 100 microns - A61K 2800/56: Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract Disclosed is a cosmetic composition having a double-shell type nano-structure. More particularly, the nano-structure of the cosmetic composition includes: a water-soluble bioactive ingredient core; a core shell containing poly(ethyleneglycol)-poly(caprolactone)-poly(ethyleneglycol) (PE-PCL-PEG) triblock copolymer in order to include the bioactive ingredient core therein; and an outer shell containing phospholipids or derivatives thereof in order to enclose the core shell therein. Such a cosmetic composition improves stability of active components which are prone to oxidation, light degradation, heat degradation, etc., is formed in a nanoparticle size which in turn shows high transdermal absorption and is very useful to prepare a cosmetic composition stably encapsulating various bioactive ingredients with anti-wrinkle effects, whitening effects, and so forth. ## Claims ### Claim 1 A cosmetic composition comprising a nano-structure, wherein the nano-structure comprises: at least two core shell compositions comprising a water-soluble bioactive ingredient core and a core shell surrounding the bioactive ingredient core, wherein the bioactive ingredient core comprises a water-soluble bioactive ingredient and wherein the core shell comprises a poly(ethyleneglycol)-poly(caprolactone)-poly(ethyleneglycol) (PEG-PCL-PEG) triblock copolymer an outer shell comprising phospholipids, wherein the at least two core shell compositions are enclosed within the outer shell; and a space between the at least two core shell compositions and the outer shell, wherein the space comprises an oil-soluble bioactive component. ### Claim 2 (depends on 1) The cosmetic composition according to claim 1, wherein the water-soluble active ingredient includes at least one selected from a group consisting of ascorbic acid 2-glucoside (AA2G), vitamin C (ascorbic acid), niacinamide, arbutine, Mulberry root extract, Broussonetia extract, magnesium ascorbyl phosphate, hydroxyproline, growth factor, peptides, N-acetyl glucosamine, and mixtures of at least two or more thereof. ### Claim 3 (depends on 1) The cosmetic composition according to claim 1, wherein the triblock copolymer has a crystallization temperature Tc, of 10 to 40° C. and a relative ratio of PEG:PCL:PEG ranging from 1:1:1 to 1:5:1, and is prepared using PEG and PCL each having a molecular weight of 400 to 3,000 g/mol. ### Claim 4 (depends on 1) The cosmetic composition according to claim 1, wherein the phospholipids include at least one selected from a group consisting of: naturally-derived saturated lecithin extracted from soybean or egg yolk; unsaturated choline compounds such a phosphatidylcholine, lysophosphatidylcholine, phosphatidyl ethanolamine; serine compounds; ethanolamine compounds; and combinations of two or more thereof. ### Claim 5 (depends on 1) The cosmetic composition according to claim 1, wherein the phospholipids are present in an amount of 0.5 to 15.0 wt. % based on a total weight of the nano-structure. ### Claim 6 (depends on 1) The cosmetic composition according to claim 1, wherein the nano-structure comprises: (a) 0.5 to 20 wt. % of the at least two core shell compositions; (b) an oil phase part including (i) 0.5 to 10.0 wt. % of oil and (ii) less than 5.0 wt. % of an oil-soluble active component; and (c) an aqueous phase part including (i) 0.5 to 15.0 wt. % of phospholipids, (ii) 10.0 to 60.0 wt. % of polyol, (iii) less than 5.0 wt. % of a water-soluble bioactive ingredient and (iv) the remainder of water, wherein the weight percents are based on 100 wt. % of the nano-structure, and wherein the oil phase part and the aqueous phase part are present in the outer shell. ### Claim 7 (depends on 6) The cosmetic composition according to claim 6, wherein the core shell composition comprises: (i) 0.1 to 5.0 wt. % of a water-soluble bioactive ingredient; (ii) 50.0 to 70.0 wt. % of oil; (iii) 0.5 to 20.0 wt. % of a triblock copolymer; and (iv) the remainder of water, wherein the weight percents are based on 100 wt. % of the core shell composition. ### Claim 8 (depends on 1) The cosmetic composition according to claim 1, wherein the oil-soluble bioactive component comprises at least one of an oil-soluble licorice, ethyl ascorbyl ether, α-bisabolol, retinol, adenosine, and a combination of two or more thereof. ### Claim 9 (depends on 1) The cosmetic composition according to claim 1, wherein the nano-structure has an average particle diameter of 300 to 500 nm. ### Claim 10 (depends on 1) The cosmetic composition according to claim 1, wherein the cosmetic composition comprises 0.001 to 30.0 wt. % of the nanostructure based on a total weight of the cosmetic composition. ### Claim 11 (depends on 1) The cosmetic composition according to claim 1, wherein the cosmetic composition is produced in any one of formulations including skin softener, skin toner, facial lotion, facial cream, massage cream, facial essence and massage pack.