# US 8,540,972 B2 · Sunscreen product comprising hydroxyapatite as physical filter

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- Number: US 8,540,972 B2
- Document ID: US8540972B2
- Status: Granted
- Kind: B2
- Application number: 13/138,687
- Filed: 2010-03-22
- Published: 2012-01-19
- Granted: 2013-09-24
- Earliest claimed: 2009-03-23
- Assignees: Kalichem Italia S.R.L.
- Applicants: Gianbattista Rastrelli; Luigi Rigano; Giancarlo Gazzaniga
- Inventors: Gianbattista Rastrelli; Luigi Rigano; Giancarlo Gazzaniga
- Web page: https://patentgrep.com/patent/US8540972B2

## CPC

- A61K 8/24: Phosphorous; Compounds thereof
- A61Q 17/04: Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
- A61K 2800/413: Nanosized, i.e. having sizes below 100 nm
- A61Q 19/02: for chemically bleaching or whitening the skin
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present invention concerns the use of hydroxyapatite as the physical sunscreening agent in synergistic association with at least one chemical sunscreening agent, in products designed for application to the skin in order to protect the same from solar UV radiation. Particularly, cosmetic compositions are described comprising the sunscreen product having screening capability, high dermal tolerance and a low whitening effect on the skin.

## Claims

### Claim 1

A sunscreen product comprising a mixture of (a) particles consisting of hydroxyapatite or a salt thereof and (b) at least one chemical sunscreening agent, wherein said (b) at least one chemical sunscreening agent and said (a) particles consisting of hydroxyapatite or a salt thereof are in a weight ratio of 10:1 to 1:3.

### Claim 2 (depends on 1)

The sunscreen product of claim 1, further comprising (c) at least one metal selected from the group consisting of zinc, magnesium, manganese, copper, sodium, potassium, lithium, aluminum, silver and bismuth, in the form of a salt of lactic acid, carbonic acid, acetic acid, C3-C18 linear fatty acid, benzoic acid, tartaric acid, citric acid, 3-hydroxypropionic acid, malic acid, succinic acid, mandelic acid, salicylic acid, and mixtures thereof.

### Claim 3 (depends on 2)

The sunscreen product of claim 2, wherein said (c) at least one metal is selected from the group consisting of zinc, magnesium, manganese and mixtures thereof, in the form of a lactic acid salt, a carbonic acid salt, and mixtures thereof.

### Claim 4 (depends on 1)

The sunscreen product of claim 1, comprising a mixture of (a) particles consisting of hydroxyapatite, (b) at least one chemical sunscreening agent and (c) at least one salt selected from the group consisting of Zn lactate, Mg lactate, Mn lactate, Zn carbonate, Mg carbonate and Mn carbonate.

### Claim 5 (depends on 1)

The sunscreen product of claim 1, wherein said (b) at least one chemical sunscreening agent is selected from derivatives of cinnamic acid and its salts, derivatives of salicylic acid and its salts, benzophenones, derivatives of aminobenzoic acid and its salts, dibenzoylmethanes, benzylidenecamphor derivatives, benzimidazole derivatives, diphenylacrylate derivatives, acrylamide derivatives, benzotriazole derivatives, triazine derivatives, benzalmalonate derivatives, aminobenzoate derivatives, and mixtures thereof.

### Claim 6 (depends on 5)

The sunscreen product of claim 5, wherein said (b) at least one chemical sunscreening agent is selected from the group consisting of para-aminobenzoic acid and its salts, N,N,N-trimethyl-4-[(2-keto-3-bornylidene)methyl]aniline methyl sulphate, 2-hydroxy-benzoic acid (3,3,5-trimethylcyclohexyl)ester, (2-hydroxy-4-methoxyphenyl)phenyl-methanone, 2-phenylbenzimidazole-5-sulphonic acid and its salts, 3,3′-(1,4-phenylenedimethylene)bis[7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulphonic acid and its salts, 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)-1,3-propanedione, alpha-(2-oxoborn-3-ylidene)toluene-4-sulphonic acid and its salts, 2-cyano-3,3-diphenyl-2-propenoic acid 2-ethylhexyl ester, polymer of N-{(2 and 4)-[2-oxo-born-3-ylidene methyl]benzyl}acrylamide, 2-ethylhexyl 4-methoxy cinnamate, ethoxylated 4-aminobenzoic acid, isopentyl 4-methoxycinnamate, 2,4,6-trianiline-(p-carbo-2′-ethylhexyl-1′-oxy)-1,3,5-triazine, drometrizole trisiloxane, benzoic acid 4,4-[[6-[[4-[[(1,1-dimethylethyl)amino]carbonyl]phenyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis,bis(2-ethylhexyl)ester, 4-methyl-benzylidene camphor, 3-benzylidene camphor, 2-ethylhexyl salicylate, 2-ethylhexyl 4-dimethylaminobenzoate, 5-benzoyl-4-hydroxy-2-methoxy-benzenesulphonic acid and its salts, 2,2′-methylene-bis-[6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)]phenol, sodium salt of 2,2′-(1,4-phenylene)bis-1H-benzimidazole-4,6-disulphonic acid, 2,2′-[6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl]bis[5-(2-ethylhexyl)oxy]phenyl, dimethicodiethylbenzal malonate, hexyl 2,[4-(diethylamino)-2-hydroxy benzoyl]-benzoate, 2-ethylhexyl 4-(dimethylamino)benzoate, terephthalylidene dicamphor sulphonic acid, methyl 2-aminobenzoate and mixtures thereof.

### Claim 7 (depends on 5)

The sunscreen product of claim 5, wherein said (b) at least one chemical sunscreening agent is selected from derivatives of cinnamic acid and its salts, derivatives of salicylic acid and its salts, benzophenones, derivatives of para aminobenzoic acid (PABA) and its salts, dibenzoylmethanes, benzylidenecamphor derivatives, and mixtures thereof.

### Claim 8 (depends on 5)

The sunscreen product of claim 5, wherein said (b) at least one chemical sunscreening agent is selected from the group consisting of 2-phenylbenzimidazole-5-sulphonic acid and its salts, 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)-1,3-propanedione, 2-ethyl-hexyl 4-methoxycinnamate, 2,4,6-trianiline-(p-carbo-2′-ethylhexyl-1′-oxy)-1,3,5-triazine, 2-ethylhexyl salicylate, hexyl 2-[4-(diethylamino)-2-hydroxy benzoyl]-benzoate, and mixtures thereof.

### Claim 9 (depends on 1)

The sunscreen product of claim 1, wherein said (b) said at least one chemical sunscreening agent and said (a) particles consisting of hydroxyapatite or a salt thereof are in a ratio of 7:1 to 1:2.

### Claim 10 (depends on 9)

The sunscreen product of claim 9, wherein said b) said at least one chemical sunscreening agent and said (a) particles consisting of hydroxyapatite or a salt thereof are in a ratio of 6.5:1 to 1:1.5.

### Claim 11 (depends on 1)

The sunscreen product of claim 1, wherein said (a) particles consisting of hydroxyapatite have a particle size of 1-200 nm.

### Claim 12 (depends on 11)

The sunscreen product of claim 11, wherein said (a) particles consisting of hydroxyapatite have a particle size of 5-96 nm.

### Claim 13 (depends on 1)

A cosmetic composition comprising the sunscreen product of claim 1.

### Claim 14 (depends on 13)

The cosmetic composition of claim 13, wherein the hydroxyapatite is in an amount not higher than 20% by weight on the composition weight.

### Claim 15 (depends on 14)

The cosmetic composition of claim 14, wherein the hydroxyapatite is in an amount of 1 to 15% by weight on the composition weight.

### Claim 16 (depends on 15)

The cosmetic composition of claim 15, wherein the hydroxyapatite is in an amount of 3 to 10% by weight on the composition weight.

### Claim 17 (depends on 16)

The cosmetic composition of claim 16, wherein the hydroxyapatite is in an amount of 4 to 7% by weight on the composition weight.

### Claim 18 (depends on 13)

The cosmetic composition of claim 13,
in the form of a sun cream, sun gel, sun milk, sun spray, sun emulsion, fluid sun emulsion, sun cream-gel, sun powder, sun lotion, sun protection mask, sun lipo-gel, sun stick, foundation with sunscreen, sun oil, sun paste, products for lightening skin, anti-wrinkle products, all for the face and/or body and/or lips and/or hair.